On Valve Interstitial Cell Signaling: The Link Between Multiscale Mechanics and Mechanobiology

Daniel P. Howsmon; Michael S. Sacks

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On Valve Interstitial Cell Signaling: The Link Between Multiscale Mechanics and Mechanobiology

机译：瓣膜间质细胞信号：多尺度力学与力学之间的联系

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Heart valves function in one of the most mechanically demanding environments in the body to ensure unidirectional blood flow. The resident valve interstitial cells respond to this mechanical environment and maintain the structure and integrity of the heart valve tissues to preserve homeostasis. While the mechanics of organ-tissue-cell heart valve function has progressed, the intracellular signaling network downstream of mechanical stimuli has not been fully elucidated. This has hindered efforts to both understand heart valve mechanobiology and rationally identify drug targets for treating valve disease. In the present work, we review the current literature on VIC mechanobiology and then propose mechanistic mathematical modeling of the mechanically-stimulated VIC signaling response to comprehend the coupling between VIC mechanobiology and valve mechanics.

机译：心脏瓣膜在人体内机械要求最高的环境中发挥作用，以确保血液单向流动。常驻的瓣膜间质细胞对这种机械环境做出反应，并维持心脏瓣膜组织的结构和完整性，以保持体内平衡。虽然器官组织细胞心脏瓣膜功能的机制已取得进展，但机械刺激下游的细胞内信号网络尚未完全阐明。这阻碍了理解心脏瓣膜机械生物学和合理确定治疗瓣膜疾病的药物靶点的努力。在目前的工作中，我们回顾了目前关于VIC机械生物学的文献，然后提出了机械刺激VIC信号反应的机械数学模型，以理解VIC机械生物学和阀门力学之间的耦合。

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来源
《Cardiovascular engineering and technology》 |2021年第1期|共13页
作者
Daniel P. Howsmon; Michael S. Sacks;
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作者单位

James T. Willerson Center for Cardiovascular Modeling and Simulation The Oden Institute for;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Valve interstitial cell; Mechanobiology; Cell signaling; Systems biology.;

机译：瓣膜间质细胞;力学学;细胞信号传导;系统生物学。;

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On Valve Interstitial Cell Signaling: The Link Between Multiscale Mechanics and Mechanobiology

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