Biomechanical Assessment of Bicuspid Aortic Valve Phenotypes: A Fluid-Structure Interaction Modelling Approach

Diana M. C. de Oliveira; Nazirul Abdullah; Naomi C. Green; Daniel M. Espino

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Biomechanical Assessment of Bicuspid Aortic Valve Phenotypes: A Fluid-Structure Interaction Modelling Approach

机译：双裂主动脉瓣膜表型的生物力学评估：流体结构相互作用建模方法

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Purpose-Bicuspid aortic valve (BAV) is a congenital heart malformation with phenotypic heterogeneity. There is no prior computational study that assesses the haemodynamic and valve mechanics associated with BAV type 2 against a healthy tricuspid aortic valve (TAV) and other BAV categories. Methods-A proof-of-concept study incorporating three-dimensional fluid-structure interaction (FSI) models with idealised geometries (one TAV and six BAVs, namely type 0 with lateral and anterior-posterior orientations, type 1 with R-L, N-R and N-L leaflet fusion and type 2) has been developed. Transient physiological boundary conditions have been applied and simulations were run using an Arbitrary Lagrangian-Eulerian formulation.

机译：目的二叶主动脉瓣（BAV）是一种具有表型异质性的先天性心脏畸形。之前没有计算研究评估与BAV 2型相关的血流动力学和瓣膜力学，与健康的三尖瓣主动脉瓣（TAV）和其他BAV类型相比。方法：开发了一项概念验证研究，包括具有理想几何结构的三维流体-结构相互作用（FSI）模型（一个TAV和六个BAV，即具有前后方向的0型、具有R-L、N-R和N-L小叶融合的1型和2型）。应用瞬态生理边界条件，并使用任意拉格朗日-欧拉公式进行模拟。

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《Cardiovascular engineering and technology》 |2020年第4期|共17页
作者
Diana M. C. de Oliveira; Nazirul Abdullah; Naomi C. Green; Daniel M. Espino;
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作者单位

Department of Mechanical Engineering University of Birmingham Birmingham B15 2TT UK;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Bicuspid aortic valve; Congenital malformation; Fluid-structure interaction; Multi-physics modelling.;

机译：双裂主动脉瓣;先天性畸形;流体结构相互作用;多物理建模。;

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1. The incidence and predictors of high-degree atrioventricular block in patients with bicuspid aortic valve receiving self-expandable transcatheter aortic valve implantation [J] . Yuan-Weixiang OU, Jing-Jing HE, Xuan ZHOU, 老年心脏病学杂志（英文版） . 2021,第010期
2. Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population [J] . Xian-bao LIU, Mei-xiang XIANG, Yu-xin HE, 浙江大学学报（英文版）（B辑：生物医学和生物技术） . 2015,第003期
3. Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid-Structure Interaction Approach [J] . Monica Emendi, Francesco Sturla, Ram P. Ghosh, Annals of Biomedical Engineering: The Journal of the Biomedical Engineering Society . 2021,第2期

机译：患者特异性双囊主动脉瓣生物力学：磁共振成像集成流体 - 结构相互作用方法
4. Systolic fluid-structure interaction model of the congenitally bicuspid aortic valve: assessment of modelling requirements [J] . May Y.S. Kuan, Daniel M. Espino Computer methods in biomechanics and biomedical engineering . 2015,第9a12期

机译：先天性双尖瓣主动脉的收缩期流体结构相互作用模型：对建模要求的评估
5. Fluid-Structure Interaction Models of Bicuspid Aortic Valves: The Effects of Nonfused Cusp Angles [J] . Lavon Karin, Halevi Rotem, Marom Gil, Journal of biomechanical engineering. . 2018,第3期

机译：流体结构相互作用型号双裂主动脉瓣膜：非熔断角度的影响
6. PATIENT-SPECIFIC VALVE DYNAMICS USING 3D FLUID-STRUCTURE INTERACTION MODELING: COMPARISON BETWEEN BICUSPID AND TRISCUSPID AORTIC VALVES [C] . V. Govindarajan, J. Mousel, S. C. Vigmostad, ASME Bioengineering Conference . 2014

机译：使用3D流体结构相互作用建模的患者特异性阀门动力学：双裂和三角形主动脉阀之间的比较
7. A study of coronary flow in the presence of geometric and mechanical abnormalities in a fluid-structure interaction model of the aortic valve. [D] . Campbell, Ian. 2008

机译：在主动脉瓣的流固耦合模型中，在存在几何和机械异常的情况下研究冠状动脉血流。
8. 3D Fluid-Structure Interaction Simulation of Aortic Valves Using a Unified Continuum ALE FEM Model [O] . Jeannette H. Spühler, Johan Jansson, Niclas Jansson, -1

机译：使用统一连续谱ALE FEM模型的主动脉瓣3D流体-结构相互作用模拟
9. Biomechanical Assessment of Bicuspid Aortic Valve Phenotypes: A Fluid–Structure Interaction Modelling Approach [O] . Diana M. C. de Oliveira, Nazirul Abdullah, Naomi C. Green, 2020

机译：双裂性主动脉瓣表术的生物力学评估：一种流体结构相互作用建模方法
10. Patient-Specific Finite Element Modeling of Biomechanical Interaction in Transcatheter Aortic Valve Implantation. [R] . Wang, Q. 2015

机译：经导管主动脉瓣植入术中生物力学相互作用的患者特异性有限元模型。

Biomechanical Assessment of Bicuspid Aortic Valve Phenotypes: A Fluid-Structure Interaction Modelling Approach

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