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首页> 外文期刊>Cerebral cortex >Anatomical Correlates of Local, Translaminar, and Transcolumnar Inhibition by Layer 6 GABAergic Interneurons in Somatosensory Cortex
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Anatomical Correlates of Local, Translaminar, and Transcolumnar Inhibition by Layer 6 GABAergic Interneurons in Somatosensory Cortex

机译：局部，译式和跨学脉冲抑制在躯体卷曲皮层中的局部，译兰蛋白和跨思科抑制的解剖学相关性

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摘要

In the vibrissal area of rodent somatosensory cortex, information on whisker stimulation is processed by neuronal networks in a corresponding cortical column. To understand how sensory stimuli are represented in a column, it is essential to identify cell types constituting these networks. Layer 6 (L6) comprises 25% of all neurons in a column. In rats, 430 of these are inhibitory interneurons (INs). Little is known about the axon projection of L6 INs with reference to columnar and laminar organization. We quantified axonal projections of L6 INs (n = 68) with reference to columns and layers in somatosensory cortex of rats. We found distinct projection types differentially targeting layers of a cortical column. The majority of L6 INs did not show a column-specific innervation, densely projecting to neighboring columns as well as the home column. However, a small fraction targeted granular and supragranular layers, where axon projections were confined to the home column. We also quantified putative innervation of pyramidal cells as a functional correlate of axonal distribution. Electrophysiological properties were not correlated to axon projection. The quantitative data on axonal projections and electrophysiological properties of L6 INs can guide future studies investigating cortical processing of sensory information at the single cell level.
机译：在啮齿类动物体感皮层的触须区，触须刺激的信息由相应皮层柱中的神经元网络处理。为了理解感官刺激是如何在一列中表现出来的，识别构成这些网络的细胞类型至关重要。第6层（L6）由一列中25%的神经元组成。在大鼠中，其中430个是抑制性中间神经元（INs）。关于L6-INs的轴突投射与柱状和层状组织的关系知之甚少。我们参考大鼠体感皮层的柱状和层，量化了L6-INs（n=68）的轴突投射。我们发现不同的投射类型以皮质柱的不同层为靶点。大多数L6-INs没有显示特定于柱的神经支配，密集地投射到相邻柱和主柱。然而，一小部分靶向颗粒层和超颗粒层，轴突投射仅限于主柱。我们还量化了锥体细胞的假定神经支配，作为轴突分布的功能相关性。电生理特性与轴突投射无关。L6-INs轴突投射和电生理特性的定量数据可以指导未来在单细胞水平上研究皮质对感觉信息的处理。

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