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首页> 外文期刊>Cerebrovascular diseases >Clinical Effectiveness and Safety Outcomes of Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke in China
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Clinical Effectiveness and Safety Outcomes of Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke in China

机译：中国急性前循环缺血性脑卒中血管内治疗的临床效果及安全性结果

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摘要

Backgrounds and Purpose: This study was aimed at investigating the outcomes and predictors for the poor functional outcome after endovascular treatment (EVT) in a large, mostly Asian population. Methods: Between January 2014 and June 2016, acute stroke patients with anterior circulation occlusion and EVT were retrospectively enrolled from 21 stroke centers in China. The main outcomes were modified Rankin Scale (0-2 as functional independence, 3-6 as poor) at 90 days, symptomatic intracranial hemorrhage (sICH) at 72 h, and death at 90 days. Logistic regression was used to identify predictors for poor functional outcome at 90 days. Results: Of the 698 patients, 304 (43.6%) patients had functional independence at 90 days. The sICH rate was 15.5% (108/698) and mortality rate at 90 days was 25.4% (177/698). Age (OR 1.04, 95% CI 1.02-1.07), National Institutes of Health Stroke Scale score at admission (11-20 vs. = 10, OR 2.38, 95% CI 1.23-4.59; = 21 vs. = 10, OR 3.66, 95% CI 1.72-7.80), baseline glucose level (OR 1.09, 95% CI 1.01-1.18), onset to groin puncture 6 h (OR 1.88, 95% CI 1.06-3.31), sICH (OR 15.49, 95% CI 5.16-46.43), and pneumonia (OR 3.15, 95% CI 1.86-5.32) were independent predictors of poor functional outcomes, while good recanalization (OR 0.26, 95% CI 0.13-0.54), preoperative Alberta Stroke Program Early CT Score 8-10 (OR 0.48, 95% CI 0.28-0.83), and good collateral flow (OR 0.50, 95% CI 0.32-0.79) were protective factors. Conclusions: This study provides evidence in real world to support the performance of EVT in acute anterior circulation stroke patients in Chinese population. Patients with small infarct core, successful recanalization, good collateral status, and short treatment delay without sICH or pneumonia may benefit from EVT. (C) 2017 S. Karger AG, Basel
机译：背景和目的：本研究旨在调查大部分亚洲人群血管内治疗（EVT）后功能不良的结果和预测因素。方法：2014年1月至2016年6月，对中国21个卒中中心的急性前循环阻塞和EVT患者进行回顾性研究。主要转归为90天时的改良Rankin评分（0-2为功能独立性，3-6为差），72小时时的症状性颅内出血（sICH），以及90天时的死亡。Logistic回归用于确定90天时功能不良结果的预测因素。结果：698例患者中，304例（43.6%）患者在90天时有功能独立性。sICH发生率为15.5%（108/698），90天死亡率为25.4%（177/698）。年龄（OR 1.04，95%可信区间1.02-1.07），美国国立卫生研究院入院时中风量表评分（11-20 vs.；=10，OR 2.38，95%可信区间1.23-4.59；；=21 vs.；=10，OR 3.66，95%可信区间1.72-7.80），基线血糖水平（OR 1.09，95%可信区间1.01-1.18），腹股沟穿刺开始时间；6小时（OR 1.88，95%可信区间1.06-3.31）、sICH（OR 15.49，95%可信区间5.16-46.43）和肺炎（OR 3.15，95%可信区间1.86-5.32）是功能预后差的独立预测因子，而良好的再通（OR 0.26，95%可信区间0.13-0.54）、术前阿尔伯塔卒中计划早期CT评分8-10（OR 0.48，95%可信区间0.28-0.83）和良好的侧支循环（OR 0.50，95%可信区间0.32-0.79）是保护因素。结论：本研究为中国人群急性前循环卒中患者的EVT表现提供了现实证据。小梗死核心、成功再通、侧支循环状态良好、治疗延迟短且无sICH或肺炎的患者可能受益于EVT。（C） 2017年巴塞尔S.卡格股份公司

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  • 来源
    《Cerebrovascular diseases》 |2017年第6期|共11页
  • 作者

    Zi Wenjie; Wang Huaiming; Yang Dong; Hao Yonggang; Zhang Meng; Geng Yu; Lin Min; Wan Yue; Shi Zhonghua; Zhou Zhiming; Wang Wei; Xu Haowen; Tian Xiguang; Lv Penghua; Wang Shuiping; Liu Wenhua; Wang Zhen; Liu Xintong; Guo Fuqiang; Zheng Dequan; Li Hua; Tu Mingyi; Jin Ping; Xiao Guodong; Liu Yuxiu; Xu Gelin; Xiong Yunyun; Liu Xinfeng;

  • 作者单位

    Nanjing Univ Dept Neurol Jinling Hosp Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Second Mil Med Univ Jinling Hosp Dept Neurol Nanjing Jiangsu Peoples R China;

    Second Mil Med Univ Jinling Hosp Dept Neurol Nanjing Jiangsu Peoples R China;

    Southern Med Univ Jinling Hosp Dept Neurol Nanjing Jiangsu Peoples R China;

    Third Mil Med Univ Daping Hosp Dept Neurol Res Inst Surg Chongqing Peoples R China;

    Zhejiang Prov Peoples Hosp Dept Neurol Hangzhou Zhejiang Peoples R China;

    Fuzhou Gen Hosp Nanjing Mil Reg Dept Neurol Fuzhou Fujian Peoples R China;

    Hubei Zhongshan Hosp Dept Neurol Wuhan Hubei Peoples R China;

    101st Hosp Peoples Liberat Army Dept Neurosurg Wuxi Peoples R China;

    Wannan Med Coll Yijishan Hosp Dept Neurol Wuhu Peoples R China;

    Yangzhou Univ Peoples Hosp Yangzhou 1 Dept Radiol Yangzhou Jiangsu Peoples R China;

    Zhengzhou Univ Affiliated Hosp 1 Dept Neurol Zhengzhou Henan Peoples R China;

    Chinese Armed Police Force Guangdong Armed Police Dept Neurol Guangzhou Guangdong Peoples R;

    Northern Jiangsu Peoples Hosp Dept Intervent Radiol Yangzhou Jiangsu Peoples R China;

    123rd Hosp Peoples Liberat Army Dept Neurol Bengbu Peoples R China;

    Wuhan 1 Hosp Dept Neurol Wuhan Hubei Peoples R China;

    Changsha Cent Hosp Dept Neurol Changsha Hunan Peoples R China;

    Guangdong Prov 2 Peoples Hosp Dept Neurol Guangzhou Guangdong Peoples R China;

    Sichuan Prov Peoples Hosp Dept Neurol Chengdu Sichuan Peoples R China;

    Xiamen Univ Hosp Peoples Liberat Army 175 Affiliated Southeast Hosp Dept Neurol Zhangzhou;

    476th Hosp Peoples Liberat Army Dept Neurol Fuzhou Fujian Peoples R China;

    Hubei Wuchang Hosp Dept Neurol Wuhan Hubei Peoples R China;

    Anhui Med Univ Dept Neurol Luan Affiliated Hosp Luan Peoples R China;

    Soochow Univ Affiliated Hosp 2 Dept Neurol Suzhou Peoples R China;

    Nanjing Univ Dept Med Stat Jinling Hosp Med Sch Nanjing Jiangsu Peoples R China;

    Nanjing Univ Dept Neurol Jinling Hosp Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Nanjing Univ Dept Neurol Jinling Hosp Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

    Nanjing Univ Dept Neurol Jinling Hosp Med Sch 305 East Zhongshan Rd Nanjing 210002 Jiangsu;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Endovascular procedures; Stroke; Tissue plasminogen activator; Thrombectomy; Outcome;

    机译：血管内程序;中风;组织纤溶酶原激活剂;血栓切除术;结果;

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