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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model
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Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model

机译：抗生素诱导的肠道微生物膨胀和硒的影响对小鼠模型中的血浆硒代蛋白和金属稳态的补充

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Selenium (Se) is a micronutrient involved in important health functions and it has been suggested to shape gut microbiota. Limited information on Se assimilation by gut microbes and the possible link with selenoproteins are available. For this purpose, conventional and gut microbiota-depleted BALB/c mice were fed a Se-supplemented diet. The absolute quantification of mice plasma selenoproteins was performed for the first time using heteroatom-tagged proteomics. The gut microbiota profile was analyzed by 16S rRNA gene sequencing. Se-supplementation modulated the concentration of the antioxidant glutathione peroxidase and the Se-transporter selenoalbumin as well as the metal homeostasis, being influenced by microbiota disruption, which suggests an intertwined mechanism. Se also modulated microbiota diversity and richness and increased the relative abundance of some health-relevant taxa (e.g., families Christensenellaceae, Ruminococcaceae, and Lactobacillus genus). This study demonstrated the potential beneficial effects of Se on gut microbiota, especially after antibiotic-treatment and the first associations between specific bacteria and plasma selenoproteins.
机译：硒（Se）是一种参与重要健康功能的微量营养素，有人认为它可以塑造肠道微生物群。关于肠道微生物对硒的吸收以及与硒蛋白的可能联系的信息有限。为此，常规和肠道微生物群缺失的BALB/c小鼠被喂食补硒饮食。首次使用杂原子标记的蛋白质组学对小鼠血浆硒蛋白进行了绝对定量。通过16S rRNA基因测序分析肠道微生物群。补硒可调节抗氧化物谷胱甘肽过氧化物酶和硒转运体硒白蛋白的浓度以及金属稳态，受微生物群破坏的影响，这表明一种相互交织的机制。硒还调节了微生物群落的多样性和丰富度，并增加了一些与健康相关的分类群（例如，克里斯滕斯内尔科、瘤胃球菌科和乳酸杆菌属）的相对丰富度。这项研究证明了硒对肠道微生物群的潜在有益作用，尤其是在抗生素治疗后，以及特定细菌和血浆硒蛋白之间的首次关联。

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