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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice
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Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice

机译：Chrysin通过调节胰岛素抗性HepG2细胞中的AMPK / PI3K / AKT信号通路和HFD / STZ诱导的C57BL / 6J小鼠来改善葡萄糖和脂质代谢紊乱

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摘要

Natural products with minor side effects have been reported to be an effective adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, and hepatoprotective. This study was designed to explore the effects and mechanism of chrysin on metabolic syndrome using insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice. The results indicated that chrysin significantly decreased insulin resistance, oxidative stress, inflammation, and liver injury. In addition, chrysin improved glycogen synthesis and fatty acid oxidation and inhibited gluconeogenesis and fatty acid synthesis by regulating GSK3 beta, G6Paes, PEPCK, SREBP1, FAS, and ACC1. Furthermore, the results of western blot and real-time PCR experiments demonstrated that chrysin modulated glucose and lipid metabolism through the AMPK/PI3K/AKT signaling pathway. Treatment with the AMPK inhibitor verified that AMPK activation is positively correlated with chrysin activity on glycolipid metabolism. This study confirms that chrysin is a potential treatment for glucose and lipid metabolism disorders.
机译：据报道，具有轻微副作用的天然产物是治疗糖脂代谢紊乱的有效辅助疗法。白杨素是一种黄酮类化合物，具有广泛的生理作用，如抗氧化、抗炎、抗糖尿病、抗高脂血症和保肝。本研究旨在利用胰岛素抵抗的HepG2细胞和HFD/STZ诱导的C57BL/6J小鼠，探讨白杨素对代谢综合征的影响及其机制。结果表明，白杨素显著降低胰岛素抵抗、氧化应激、炎症和肝损伤。此外，白杨素通过调节GSK3β、G6Paes、PEPCK、SREBP1、FAS和ACC1，改善糖原合成和脂肪酸氧化，抑制糖异生和脂肪酸合成。此外，western-blot和real-timepcr实验的结果表明，白杨素通过AMPK/PI3K/AKT信号通路调节糖脂代谢。AMPK抑制剂治疗证实AMPK激活与糖脂代谢的白杨素活性呈正相关。这项研究证实白杨素是治疗糖脂代谢紊乱的潜在药物。

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