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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice
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Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

机译：通过调节小鼠的胆汁酸性代谢和肠道微生物，从整粒燕麦中的黄酮类化合物缓解了高脂饮食诱导的高脂血症

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摘要

A high-fat diet (HFD) causes hyperlipidemia, which worsens disturbances in bile acid (BA) metabolism and gut microbiota. This study aimed to investigate the regulation of flavonoids from whole-grain oat (FO) on BA metabolism and gut microbiota in HFD-induced hyperlipidemic mice. The experiment results showed that FO improved serum lipid profiles and decreased body weight and lipid deposition in HFD-fed mice. Through real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot assays, by up-regulating the expression of PPARa, CPT-1, CYP7A1, FXR, TGR5, NTCP, and BSTP, and downregulating those of SREBP-1c, FAS, and ASBT, FO suppressed lipogenesis, promoted lipolysis and BA synthesis, and efflux to faeces via the FXR pathway. 16s rRNA sequencing revealed that FO significantly increased Akkermansia and significantly decreased Lachnoclostridium, Blautia, Colidextribacter, and Desulfovibrio. Spearman's correlation analysis showed that these bacteria were strongly correlated with hyperlipidemia-related parameters. Therefore, our results indicated that FO possessed an antihyperlipidemic effect via regulating the gut-liver axis, i.e., BA metabolism and gut microbiota.
机译：高脂饮食（HFD）会导致高脂血症，从而加剧胆汁酸（BA）代谢和肠道微生物群的紊乱。本研究旨在探讨全麦燕麦黄酮（FO）对HFD诱导的高脂血症小鼠BA代谢和肠道微生物群的调节作用。实验结果表明，FO改善了HFD喂养小鼠的血脂谱，降低了体重和脂质沉积。通过实时定性聚合酶链反应（RT-qPCR）和蛋白质印迹分析，上调PPARa、CPT-1、CYP7A1、FXR、TGR5、NTCP和BSTP的表达，下调SREBP-1c、FAS和ASBT的表达，FO抑制脂肪生成，促进脂肪分解和BA合成，并通过FXR途径流出粪便。16s rRNA测序显示，FO显著增加阿克曼氏菌，显著减少Lachnoclostridium、Blautia、大肠杆菌和脱硫弧菌。斯皮尔曼的相关分析表明，这些细菌与高脂血症相关参数密切相关。因此，我们的结果表明，FO通过调节肠肝轴，即BA代谢和肠道微生物群，具有降血脂作用。

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