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首页> 外文期刊>Journal of Applied Polymer Science >Self-assemblyandsol-to-geltransition of thermosensitivemethoxy-polyethylene glycol-polyalanineblock copolymer hydrogels
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Self-assemblyandsol-to-geltransition of thermosensitivemethoxy-polyethylene glycol-polyalanineblock copolymer hydrogels

机译：热溶剂嘧啶 - 聚乙二醇 - 聚酰氯聚乙烯 - 聚酰氨氨氨氨氨醇 - 聚酰氨氨溴嵌段共聚物水凝胶的自我组装

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摘要

Certain amphiphilic polymers can self-assemble to form various structures, such as micelles and hydrogels in aqueous medium, depending on the concentration or temperature. These different structures have found many applications in biomedical and material processing fields. The assembly processes of the polypeptide-containing diblock copolymer, methoxy poly(ethylene glycol)-block-poly(L-alanine) (mPEG-PA), was studied to elucidate the relationship between different structures with parameters such as chain lengths (volume fraction) of the two blocks, molecular weights, medium polarity, temperature, and concentration. Gelation mechanism was especially focused in the study. Various solution-cast morphologies observed by scanning electron microscopy (SEM) imaging including cylinders and micelles aggregates can be obtained by using solvents with different polarity for casting with simply tuning the chain lengths. The sol-to-gel transition mechanism can be best explained by phase separation between polymer-rich and water-rich phases. It might be spinodal decomposition process to cause the phase separation. Furthermore, the branch and flack structures can be observed due to phase separation mechanism and different chain lengths by SEM images. This result offers new insights into behavior of mPEG-PA system, enabling more controlled manipulation to various applications.
机译：根据浓度或温度的不同，某些两亲性聚合物可以自组装形成各种结构，例如胶束和水凝胶。这些不同的结构在生物医学和材料加工领域有很多应用。研究了含多肽的二嵌段共聚物甲氧基聚乙二醇-嵌段聚L-丙氨酸（mPEG-PA）的组装过程，以阐明不同结构与两个嵌段的链长（体积分数）、分子量、介质极性、温度和浓度等参数之间的关系。凝胶机理是本研究的重点。通过扫描电子显微镜（SEM）成像观察到的各种溶液浇铸形态，包括圆柱体和胶束聚集体，可以通过使用不同极性的溶剂浇铸获得，只需调整链长即可。溶胶-凝胶转变机制可以通过富聚合物和富水相之间的相分离得到最好的解释。可能是调幅分解过程导致了相分离。此外，由于相分离机制和不同的链长，SEM图像可以观察到树枝状和片状结构。这一结果为mPEG PA系统的行为提供了新的见解，使得对各种应用程序的操作更加可控。

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