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首页> 外文期刊>Journal of Applied Polymer Science >La3+ modified poly(gamma-glutamic acid) hydrogels with high strength and anti-swelling property for cartilage regeneration
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La3+ modified poly(gamma-glutamic acid) hydrogels with high strength and anti-swelling property for cartilage regeneration

机译：La3 +改性聚（γ-谷氨酸）水凝胶，具有高强度和抗溶胀性的软骨再生性

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摘要

The applications of synthetic hydrogels in cartilage regeneration are usually limited by their weak mechanical properties, uncontrolled swelling/degradation, and insufficient osteogenic activity. Developing tough hydrogels have been attracting great attention in biomedical engineering. In this study, a high strength and tough poly(gamma-glutamic acid) (gamma-PGA) hydrogels with excellent anti-swelling property were developed by immersing as-prepared gamma-PGA hydrogels in LaCl3 aqueous solution. Results revealed that the concentration of LaCl3 aqueous solution has great influence on the mechanical properties of gamma-PGA hydrogels. The tensile strength of gamma-PGA hydrogels improved from 0.12 +/- 0.02 MPa to 14.65 +/- 0.48 MPa when LaCl3 concentration was 0.15 M. Moreover, the swelling ratio decreased from 1035.75 +/- 33.16% to 18.21 +/- 3.08%. The morphology and microstructure of La3+ reinforced gamma-PGA hydrogels were characterized by SEM/EDS, FT-IR and XPS. Furthermore, in vitro cytocompatibility of La3+ reinforced gamma-PGA hydrogels was evaluated via MC3T3-E1 cells. Finally, this study provides a facile and effective strategy for modifying the mechanical and swelling properties of gamma-PGA-based hydrogels, which offers great potential applications in cartilage repair and regeneration.
机译：合成水凝胶在软骨再生中的应用通常受到机械性能差、膨胀/降解不受控制以及成骨活性不足的限制。开发坚韧的水凝胶在生物医学工程中一直备受关注。在本研究中，通过将制备的γ-PGA水凝胶浸入LaCl3水溶液中，制备了具有优异抗溶胀性能的高强度和韧性聚γ-PGA水凝胶。结果表明，LaCl3水溶液的浓度对gamma-PGA水凝胶的力学性能有很大影响。当LaCl3浓度为0.15 M时，γ-PGA水凝胶的拉伸强度从0.12+/-0.02 MPa提高到14.65+/-0.48 MPa。此外，溶胀率从1035.75+/-33.16%降低到18.21+/-3.08%。利用SEM/EDS、FT-IR和XPS对La3+增强γ-PGA水凝胶的形貌和微观结构进行了表征。此外，通过MC3T3-E1细胞评估La3+增强γ-PGA水凝胶的体外细胞相容性。最后，本研究为改善γ-PGA水凝胶的力学和溶胀性能提供了一种简便有效的策略，在软骨修复和再生方面具有巨大的潜在应用前景。

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