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首页> 外文期刊>Journal of Applied Polymer Science >A novel cationic waterborne polyurethane coating modified by chitosan biguanide hydrochloride with application potential in medical catheters
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A novel cationic waterborne polyurethane coating modified by chitosan biguanide hydrochloride with application potential in medical catheters

机译：用壳聚糖双胍盐酸盐改性新型阳离子水运聚氨酯涂料，在医用导管中具有应用潜力

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摘要

This study reported the synthesis and properties of a new cationic waterborne polyurethane coating. In this work, a chitosan derivative, chitosan biguanide hydrochloride (CSGH), was synthesized, which was used as a blocking agent and cross-linking agent to participate in the copolymerization of waterborne polyurethane (WPU) and a bioactive ingredient to enhance the biocompatibility of the coating. FTIR results demonstrated the reaction of CSGH with WPU. Moreover, the particle size distribution of the emulsion and SEM results showed that CSGH and WPU were well integrated. Benefiting from the formation of the cross-linking network, the thermodynamic properties of the coating were significantly improved. Furthermore, due to adding 3 wt% CSGH, the water contact angle of the coating surface decreased from 97.01 degrees to 69.30 degrees, indicating that the coating surface changed from hydrophobic to hydrophilic. And a specific resistance to Staphylococcus aureus and Escherichia coli was exhibited without cytotoxicity, the resistance rates could reach 85% and 91% respectively. It is highlighted that this WPU-CSGH coating has great application potential in the field of medical interventional catheters.
机译：本文报道了一种新型阳离子水性聚氨酯涂料的合成及性能。本研究合成了一种壳聚糖衍生物，壳聚糖双胍盐酸盐（CSGH），将其用作封端剂和交联剂，参与水性聚氨酯（WPU）和生物活性成分的共聚，以提高涂层的生物相容性。FTIR结果表明CSGH与WPU发生了反应。此外，乳液的粒度分布和SEM结果表明，CSGH和WPU的结合良好。由于交联网络的形成，涂层的热力学性能得到显著改善。此外，由于添加3 wt%CSGH，涂层表面的水接触角从97.01度降低到69.30度，表明涂层表面从疏水性变为亲水性。对金黄色葡萄球菌和大肠杆菌表现出特异性耐药性，且无细胞毒性，耐药率分别可达85%和91%。强调了WPU-CSGH涂层在医用介入导管领域的巨大应用潜力。

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