In vitro and in vivo evaluation of degradability and biocompatibility of poly(p-dioxanone) hemostatic clips for laparoscopic surgery

Zheng Heng; Peng Haitao; Wang Peng; Li Hong; Li Lin; Du Yan; Lv Guoyu

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In vitro and in vivo evaluation of degradability and biocompatibility of poly(p-dioxanone) hemostatic clips for laparoscopic surgery

机译：在体外和体内评估聚（p-Dioxanone）腹腔镜手术止血夹的降解性和生物相容性

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For the clinical application of biodegradable hemostatic surgical clips in laparoscopic surgery, it is necessary to determine their degradability and biocompatibility. Herein, in vitro and in vivo studies were undertaken to evaluate the degradability and biocompatibility of bioabsorbable clips made of poly(p-dioxanone). Changes in weight loss, pull-off force, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) of the poly(p-dioxanone) clips were determined after they were degraded in deionized water and phosphate buffer saline for the in vitro experiment and in laparoscopic models of bile duct ligation(BDL) and right gastroepiploic artery ligation(GEAL) using New Zealand white rabbits for the in vivo experiment. Changes in weight loss and pull-off force were greater in the in vivo experiment than the in vitro experiment. DSC showed the greatest variation in the degree of crystallinity of the clips degraded in deionized water. Stark differences in SEM were observed after 4 weeks of degradation both in vitro and in vivo. Furthermore, the cytocompatibility of the clips was considered satisfactory because the L929 cells could adhere to the clips and proliferate adequately in the presence of the clip extract. Biocompatibility was inferred based on the histological analysis of BDL and GEAL, no significant inflammatory responses were observed after 4 weeks of ligation.

机译：为了在腹腔镜手术中临床应用生物可降解止血手术夹，有必要确定其降解性和生物相容性。在此，进行了体外和体内研究，以评估由聚（对二恶烷酮）制成的生物可吸收夹的降解性和生物相容性。失重、拉脱力、差示扫描量热法（DSC）的变化，在去离子水和磷酸盐缓冲盐水中降解聚对二恶烷酮夹进行体外实验后，以及在腹腔镜胆管结扎（BDL）和右侧胃网膜动脉结扎（GEAL）模型中使用新西兰大白兔进行体内实验后，测定了聚对二恶烷酮夹的扫描电子显微镜（SEM）。与体外实验相比，体内实验中的体重损失和牵引力变化更大。DSC显示在去离子水中降解的片段结晶度变化最大。体外和体内降解4周后，扫描电镜观察到了明显的差异。此外，这些片段的细胞相容性令人满意，因为L929细胞可以粘附在片段上，并在片段提取物存在的情况下充分增殖。根据BDL和GEAL的组织学分析推断生物相容性，结扎4周后未观察到明显的炎症反应。

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来源
《Journal of Applied Polymer Science》 |2021年第32期|共12页
作者
Zheng Heng; Peng Haitao; Wang Peng; Li Hong; Li Lin; Du Yan; Lv Guoyu;
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作者单位

Sichuan Univ Coll Phys Chengdu 610065 Sichuan Peoples R China;

Sichuan Univ Coll Phys Chengdu 610065 Sichuan Peoples R China;

Sichuan Guona Technol Co Chengdu Sichuan Peoples R China;

Sichuan Univ Coll Phys Chengdu 610065 Sichuan Peoples R China;

Sichuan Univ Coll Phys Chengdu 610065 Sichuan Peoples R China;

Sichuan Univ Coll Phys Chengdu 610065 Sichuan Peoples R China;

Sichuan Univ Coll Phys Chengdu 610065 Sichuan Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类高分子化合物工业（高聚物工业）;
关键词
biodegradeable; bioengineering; biomaterials; biomedical applications;

机译：生物降解;生物化;生物材料;生物医学应用;

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In vitro and in vivo evaluation of degradability and biocompatibility of poly(p-dioxanone) hemostatic clips for laparoscopic surgery

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