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首页> 外文期刊>Journal of Applied Polymer Science >Methoxy polyethylene glycol-cholesterol modified soy lecithin liposomes for poorlywater-solubleanticancer drug delivery
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Methoxy polyethylene glycol-cholesterol modified soy lecithin liposomes for poorlywater-solubleanticancer drug delivery

机译：甲氧基聚乙二醇 - 胆固醇改性大豆卵磷脂脂质脂素脂质脂素酸盐糖尿病药物递送

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摘要

Soy lecithin liposomes (SLP) were prepared and partially surface modified with methoxy polyethylene glycol-cholesterol conjugate (mPEG-Chol) to improve its poorly-soluble-water-anticancer-drugs delivery efficiency. Paclitaxel (PTX) was used as the model drug and the PTX/SLP@mPEG was successfully developed with the optimal mass ratio of mPEG-Chol determined at 4% in the SLP@mPEG formulation. The optimal SLP@mPEG formulation had a particle size range of 161.80 +/- 1.51 nm and a negative surface charge of -54.30 +/- 1.40 mV. Besides, a sustained drug release profile of 72 h and an encapsulation efficiency of 87.48 +/- 0.70% was recorded. Moreover, in vitro cytotoxicity assays demonstrated that SLP@mPEG is nontoxic and cytocompatible. Overall, these obtained results provide insights into the potential of SLP@mPEG as a platform for the development of more effective therapies against cancers.
机译：制备了大豆卵磷脂脂质体（SLP），并用甲氧基聚乙二醇-胆固醇偶联物（mPEG-Chol）对其进行部分表面修饰，以提高其难溶性水抗癌药物的释放效率。以紫杉醇（PTX）为模型药物，以PTX为模型药物/SLP@mPEG成功制备了mPEG-Chol的最佳质量比为4%SLP@mPEG配方。最优SLP@mPEG配方的粒径范围为161.80+/-1.51 nm，表面负电荷为-54.30+/-1.40 mV。此外，还记录了72小时的缓释曲线和87.48+/-0.70%的包封率。此外，体外细胞毒性试验表明SLP@mPEG无毒且细胞相容。总的来说，这些获得的结果提供了对SLP@mPEG作为开发更有效的癌症治疗方法的平台。

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