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首页> 外文期刊>Journal of Applied Polymer Science >Developing antibacterial surgical adhesives: An enhancement of cyanoacrylate polymers
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Developing antibacterial surgical adhesives: An enhancement of cyanoacrylate polymers

机译：显影抗菌外科粘合剂：氰基丙烯酸酯聚合物的增强

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摘要

Surgical site infections (SSIs) and traumatic wounds have a significant risk of becoming contaminated by microbial pathogens of both endogenous and nosocomial origins, including Staphylococcus aureus and Enterococci sp.. One preventative approach is to protect wounds from infection by using a rapidly curing adhesive to seal the wound and prevent further contamination. Here, we demonstrate the covalent incorporation of an antimicrobial, quaternary ammonium chloride monomer (quat) into a 2-octyl cyanoacrylate (2oc) polymer adhesive. Copolymerization was confirmed via nuclear magnetic resonance spectroscopy. Cytotoxicity of the copolymer was assessed against: S. epidermidis and E. coli, and 3T3 mouse fibroblasts. The CA-Quat polymer was found to exhibit dose-dependent bacteriostatic and bactericidal effects against both E. coli and S. epidermidis, importantly without showing any demonstrable toxicity against mammalian 3T3 fibroblast cells. The described experiments provide promising data to suggest successful copolymerization, effective antibacterial properties, and remarkably low cytotoxic effects of the copolymer on mammalian cells.
机译：手术部位感染（SSI）和创伤性伤口有被内源性和医院内来源的微生物病原体污染的重大风险，包括金黄色葡萄球菌和肠球菌。。一种预防方法是使用快速固化的粘合剂密封伤口，防止进一步污染，从而保护伤口免受感染。在这里，我们展示了抗菌剂季铵盐氯化物单体（quat）与氰基丙烯酸2-辛酯（2oc）聚合物粘合剂的共价结合。通过核磁共振波谱证实了共聚反应。对该共聚物的细胞毒性进行了评估：表皮葡萄球菌和大肠杆菌，以及3T3小鼠成纤维细胞。研究发现，CA-Quat聚合物对大肠杆菌和表皮葡萄球菌均表现出剂量依赖性的抑菌和杀菌效果，重要的是对哺乳动物3T3成纤维细胞没有任何明显的毒性。所述实验提供了有希望的数据，表明共聚物成功共聚、有效抗菌性能以及对哺乳动物细胞的显著低细胞毒性作用。

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