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首页> 外文期刊>Journal of Applied Polymer Science >Biocomposite scaffolds for 3D cell culture: Propolis enriched polyvinyl alcohol nanofibers favoring cell adhesion
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Biocomposite scaffolds for 3D cell culture: Propolis enriched polyvinyl alcohol nanofibers favoring cell adhesion

机译：用于3D细胞培养的生物复合支架：蜂胶富含聚乙烯醇纳米纤维，有利于细胞粘附

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摘要

The objective of this work is generation of propolis/polyvinyl alcohol (PVA) scaffold by electrospinning for 3D cell culture. Here, PVA used as co-spinning agent since propolis alone cannot be easily processed by electrospinning methodology. Propolis takes charge in maximizing biological aspect of scaffold to facilitate cell attachment and proliferation. Morphological analysis showed size of the electrospun nanofibers varied between 172-523 nm and 345-687 nm in diameter, for non-crosslinked and crosslinked scaffolds, respectively. Incorporation of propolis resulted in desired surface properties of hybrid matrix, where hybrid scaffolds highly favored protein adsorption. To examine cell compatibility, NIH-3T3 and HeLa cells were seeded on propolis/PVA hybrid scaffold. Results confirmed that integration of propolis supported cell adhesion and cell proliferation. Also, results indicated electrospun propolis/PVA hybrid scaffold provide suitable microenvironment for cell culturing. Therefore, developed hybrid scaffold could be considered as potential candidate for 3D cell culture and tissue engineering.
机译：本研究的目的是通过静电纺丝技术制备蜂胶/聚乙烯醇（PVA）三维细胞培养支架。这里，PVA用作共纺剂，因为蜂胶本身不容易通过静电纺丝方法进行加工。蜂胶负责最大化支架的生物学方面，以促进细胞附着和增殖。形态分析表明，对于非交联和交联支架，静电纺丝纳米纤维的直径分别在172-523 nm和345-687 nm之间变化。蜂胶的加入使混合基质的表面性质达到了预期的效果，而混合支架非常有利于蛋白质的吸附。为了检测细胞相容性，将NIH-3T3和HeLa细胞接种在蜂胶/PVA混合支架上。结果证实蜂胶的整合支持细胞粘附和细胞增殖。结果还表明，静电纺蜂胶/PVA复合支架为细胞培养提供了合适的微环境。因此，所研制的复合支架有望成为三维细胞培养和组织工程的候选材料。

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