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首页> 外文期刊>Journal of Applied Polymer Science >PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti-biofilm product
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PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti-biofilm product

机译：PVA / PMMA聚合物混合复合电纺纳米纤维垫及其潜在用作抗生物膜产品

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Bacterial infections have increased dramatically due to microbial biofilm formation resulting in chronic pathological conditions in human subjects. Microbial biofilm causes poor drug penetration and antibiotic resistance, which has made site-specific sustained drug delivery the most appropriate option. Our work entails fabrication of ciprofloxacin hydrochloride (CPX) loaded nanofibers using polyvinyl alcohol (PVA) and poly(meth) methacrylate (PMMA) employing electrospinning method to form PVA:PMMA:CPX nanofibers mat. These nanofibers mat were optimized, characterized, and further subjected to anti-biofilm activity. Microscopic images revealed average nanofibers diameter of 243 +/- 80 nm with smooth surface morphology. Analytical graphs and thermal analysis confirmed drug encapsulation and drug-polymer compatibility. In vitro studies demonstrated sustained release of CPX for 22 days displaying Hixon Crowell and two-stage desorption kinetics. Anti-biofilm activity showed zones of inhibition 3.0 +/- 0.5 cm, 2.8 +/- 0.1 cm, 2.9 +/- 0.2 cm for Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, respectively which was well above the minimum inhibitory concentration levels of the bacteria forming biofilm. Conclusively, these nanofibers mat have potential to be used as an anti-biofilm product.
机译：由于微生物生物膜的形成导致人类受试者出现慢性疾病，细菌感染急剧增加。微生物生物膜导致药物渗透性差和抗生素耐药性，这使得定点持续给药成为最合适的选择。我们的工作涉及使用聚乙烯醇（PVA）和聚甲基丙烯酸甲酯（PMMA）通过静电纺丝方法制备负载盐酸环丙沙星（CPX）的纳米纤维，以形成PVA:PMMA:CPX纳米纤维毡。这些纳米纤维垫经过优化、表征，并进一步具有抗生物膜活性。显微图像显示纳米纤维的平均直径为243+/-80nm，表面光滑。分析图和热分析证实了药物包封和药物-聚合物相容性。体外研究表明，CPX持续释放22天，显示出Hixon-Crowell和两阶段解吸动力学。抗生物膜活性显示，大肠杆菌、金黄色葡萄球菌、粪肠球菌的抑制区分别为3.0+/-0.5 cm、2.8+/-0.1 cm、2.9+/-0.2 cm，远高于形成生物膜的细菌的最低抑制浓度水平。总之，这些纳米纤维垫有潜力用作抗生物膜产品。

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