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首页> 外文期刊>Journal of Applied Polymer Science >Characterization of minocycline loaded chitosan/polyethylene glycol/glycerol blend films as antibacterial wound dressings
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Characterization of minocycline loaded chitosan/polyethylene glycol/glycerol blend films as antibacterial wound dressings

机译：米诺环素载壳聚糖/聚乙二醇/甘油共混膜的表征作为抗菌伤口敷料

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摘要

Wound care has been a challenging subject for medical teams and researchers. Bacterial infections are one of the most serious complications in injured skins that often affect healing process. Antibacterial wound dressings can be used to facilitate wound healing process. The purpose of this study is to fabricate chitosan (Chito)/polyethylene glycol (PEG) antibacterial wound dressing doped with minocycline, and to evaluate the influence of composition ratio on the blending properties of the films. To improve the mechanical properties of these films, we examined various amounts of glycerol as a plasticizer. Moreover, we investigated morphological and mechanical aspects, water uptake, degradation, water vapor transmission and wettability properties of the films prepared with various ratios of Chito/PEG/Gly. Assessment of mechanical properties revealed that film containing 80:20 ratio Chito/PEG with 40 PHR Gly content exhibits the highest ultimate tensile strength and elongation at break (9.74 MPa and 45.73% respectively). Furthermore, results demonstrated that upon increasing PEG and Gly contents, degradability and hydrophilicity of the films increased whereas water uptake decreased. Water vapor transmission rate of the films was close to the range of 530-1200 g/m(2)d, indicating that the as formed films are possible candidates for dressing low exudate wounds or burns. Minocycline loaded films exhibited a biphasic drug release profile and it was more effective on gram-positive bacteria than on gram-negative bacteria. The polymeric film with the highest amount of loaded drug (2%) exhibited insignificant cytotoxicity (88%) against normal fibroblast cell line.
机译：伤口护理一直是医疗团队和研究人员面临的一个挑战性课题。细菌感染是受伤皮肤最严重的并发症之一，通常会影响愈合过程。抗菌伤口敷料可用于促进伤口愈合过程。本研究的目的是制备掺杂有米诺环素的壳聚糖（Chito）/聚乙二醇（PEG）抗菌伤口敷料，并评估组成比对薄膜共混性能的影响。为了改善这些薄膜的机械性能，我们研究了不同量的甘油作为增塑剂。此外，我们还研究了不同Chito/PEG/Gly比例制备的薄膜的形态和力学性能、吸水率、降解率、水蒸气透过率和润湿性。力学性能评估显示，含有80:20比、40份甘氨酸含量的壳聚糖/聚乙二醇的薄膜具有最高的极限拉伸强度和断裂伸长率（分别为9.74 MPa和45.73%）。此外，结果表明，随着PEG和甘氨酸含量的增加，薄膜的降解性和亲水性增加，而吸水率降低。薄膜的水蒸气透过率接近530-1200 g/m（2）d，这表明所形成的薄膜可能用于包扎低渗出性伤口或烧伤。二甲胺四环素载药膜呈现双相药物释放曲线，对革兰氏阳性细菌比对革兰氏阴性细菌更有效。载药量最高（2%）的聚合物膜对正常成纤维细胞系的细胞毒性不显著（88%）。

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