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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis and evaluating of carbon nanoallotrope-biomacromolecule gel composites as drug delivery systems
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Synthesis and evaluating of carbon nanoallotrope-biomacromolecule gel composites as drug delivery systems

机译：碳纳瓦洛岩 - 生物咯咯块凝胶复合材料作为药物递送系统的合成与评价

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This work was done to assess the role of precursors (agro and graphite) on performance of carbon nanoallotropes-biomacromolecules composite as drug delivery for controlling the release of niacin. In this respect graphene oxide and bagasse-based carbon oxide were synthesized and chelated with chitosan (Cs-GO and Cs-Co). These gel composites were characterized by many techniques [morphology, differential scanning calorimetry, Fourier-transform infrared spectroscopy, swelling, encapsulation efficiency (EE) and loading (L) % of niacin. Another series of experiments was carried out for studying the role of replacing part of carbon nanoallotrope by carboxymethyl cellulose (CMC) on performance of produced drug carries, these systems were coded as Cs-GO-CMC and Cs-Co-CMC. The data showed that, the Cs-GO gel composite provided maximum release of NA, at 5 h, for pH's simulated gastric and intestinal fluids; pH. 2.1 and pH 7.4 (1120 mg/L and 757 mg/L). The incorporation of CMC is not acceptable as it provided low drug release together with burst release of NA-drug, and consequently possible caused tissue irritation or toxicity in the human body. The Cs-GO and Cs-CO systems with relatively low drug loading were recommended for their better controllability system to NA release, which prolonging benefit of human with niacin. The NA release from all investigated gels followed Fickian and non-Fickian diffusion mechanisms.
机译：这项工作是为了评估前体（农用和石墨）对碳纳米同素异形体生物大分子复合物作为药物载体控制烟酸释放的作用。在这方面，合成了氧化石墨烯和甘蔗渣基碳氧化物，并与壳聚糖（Cs-GO和Cs-Co）螯合。这些凝胶复合物通过多种技术（形态学、差示扫描量热法、傅里叶变换红外光谱、溶胀、包封效率（EE）和烟酸负载量（L%）进行了表征。还进行了一系列实验，以研究羧甲基纤维素（CMC）替代部分碳纳米同素异形体的作用根据生产的药物载体的性能，这些系统被编码为Cs GO CMC和Cs Co CMC。数据显示，Cs-GO凝胶复合物在5小时时为pH的模拟胃液和肠液提供了最大的钠释放量；pH值为2.1和7.4（1120 mg/L和757 mg/L）。CMC的加入是不可接受的，因为它提供了低药物释放和NA药物的突发释放，因此可能会在人体内引起组织刺激或毒性。建议使用载药量相对较低的Cs-GO和Cs-CO系统，因为它们对NA释放具有更好的控制性，从而延长烟酸对人体的益处。所有研究凝胶的钠释放均遵循Fickian和非Fickian扩散机制。

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