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首页> 外文期刊>Journal of Applied Polymer Science >Preparation, characterization, and antibacterial activity of chitosan/silicone rubber filled zeolite, silver, and copper nanocomposites against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus
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Preparation, characterization, and antibacterial activity of chitosan/silicone rubber filled zeolite, silver, and copper nanocomposites against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

机译：壳聚糖/硅橡胶填充沸石，银和铜纳米复合材料的制备，表征和抗菌活性对铜绿假单胞菌和甲氧西林金黄色葡萄球菌

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摘要

The ongoing emergence of antibiotic-resistant bacteria has become one of the biggest threats to global health and development today. Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) are important antibiotic-resistant bacteria due to their increasing resistance to a broad array of antimicrobial agents. Herein, we developed a novel antibacterial nanocomposite based on chitosan and liquid silicone rubber filled zeolite-A, Ag, and Cu nanoparticles with remarkable antibacterial activity against P. aeruginosa and MRSA. The antibacterial activity of the nanocomposite was studied by disc diffusion and broth culture methods. Besides, the mechanical properties, wetting behavior, and chemical structure of the present nanocomposite were also investigated. The results exhibited that the inhibition zone diameter of the nanocomposite for P. aeruginosa and MRSA were 40 and 27 mm, respectively. It also took approximately 1 h to inhibit the growth of the tested bacteria. The nanocomposite sample with a thickness of around 1 mm showed an elastic elongation of nearly 49% and a contact angle of roughly 120 degrees. Thus, the present nanocomposite was found to be useful in killing and inhibiting the growth of P. aeruginosa and MRSA, and it could also be qualified as a superior elastic and hydrophobic material.
机译：耐药性细菌的不断出现已成为当今全球健康和发展的最大威胁之一。铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌（MRSA）是重要的耐抗生素细菌，因为它们对多种抗菌药物的耐药性不断增加。在此，我们开发了一种基于壳聚糖和液体硅橡胶填充沸石-a、银和铜纳米颗粒的新型抗菌纳米复合材料，对铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌具有显著的抗菌活性。通过圆盘扩散法和肉汤培养法研究了纳米复合材料的抗菌活性。此外，还研究了该纳米复合材料的力学性能、润湿行为和化学结构。结果表明，纳米复合材料对铜绿假单胞菌和MRSA的抑制区直径分别为40和27mm。抑制受试细菌的生长也需要大约1小时。厚度约为1mm的纳米复合材料样品显示出近49%的弹性伸长率和约120度的接触角。因此，本发明的纳米复合物被发现在杀死和抑制铜绿假单胞菌和MRSA的生长方面是有用的，并且它也可以被鉴定为一种优良的弹性和疏水性材料。

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