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首页> 外文期刊>Journal of Applied Polymer Science >Polymer matrices on the basis of polyacrylamide and beta-cyclodextrin-containing pseudorotaxane for prolonged drug release: Synthesis and properties
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Polymer matrices on the basis of polyacrylamide and beta-cyclodextrin-containing pseudorotaxane for prolonged drug release: Synthesis and properties

机译：聚合物基质基于聚丙烯酰胺和含β-环糊精的假素的延长药物释放：合成和性能

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摘要

Polymer cross-linked matrices based on polyacrylamide (PAA) and beta-cyclodextrin-pseudorotaxane have been designed. The structure and properties of the objects synthesized were confirmed and studied by a series of methods, involving ultraviolet-, Fourier transform infrared-spectroscopy, thermal mass spectrometry, DSC, X-ray diffraction analysis (WAXS and SAXS). Desorption kinetics (especially significant slowing of desorption process) of some drugs, like metoprolol succinate and loratadine from obtained polymer matrices is shown to be optimal with 10 wt% beta-CD-pseudorotaxane in their structure.
机译：设计了基于聚丙烯酰胺（PAA）和β-环糊精伪轮烷的聚合物交联基质。通过紫外、傅里叶变换红外光谱、热质谱、DSC、X射线衍射分析（WAXS和SAXS）等一系列方法对合成物的结构和性能进行了确认和研究。一些药物（如琥珀酸美托洛尔和氯雷他定）从获得的聚合物基质中的解吸动力学（尤其是解吸过程的显著放缓）表明，在结构中含有10 wt%β-环糊精假轮烷的情况下是最佳的。

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