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首页> 外文期刊>Journal of Applied Polymer Science >Polycaprolactone/alendronate systems intended for production of biomaterials
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Polycaprolactone/alendronate systems intended for production of biomaterials

机译：用于生产生物材料的聚己内酯/醛膦酸酯系统

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摘要

Sodium alendronate (ALD) is a bisphosphonate used to treat osteoporosis. However, its oral administration has been associated with side effects as gastroesophageal reflux. Moreover, there are some particularities for the intake of the medicine, which also hinder the patient's compliance, for example, the instruction that it has to be taken with an empty stomach, 30 to 60 min before breakfast and avoid the decubitus position after using the drug. Therefore, biomaterials for applications in osteoporotic bones are a good alternative. Thus, this work aimed to produce a Polycaprolactone (PCL) and ALD-based powder as a supply to build biomaterials by selective laser sintering, compression molding (CM), solvent casting (SC), among others. The powder was produced by coating the ALD particles with PCL and films were produced by SC and CM techniques. The samples were characterized by Scanning Electron Microscopy, Energy-dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectrometry and thermal analysis. Furthermore, the drug release was evaluated by UV-Vis spectroscopy. Results showed that ALD particles were successfully coated by PCL and applied to the production of biomaterials, highlighting its potential in the treatment of osteoporosis.
机译：阿仑膦酸钠（ALD）是一种用于治疗骨质疏松症的双膦酸盐。然而，其口服给药与胃食管反流等副作用有关。此外，药物的服用也有一些特殊性，这也会阻碍患者的依从性，例如，指示必须在早餐前30至60分钟空腹服用，并避免使用药物后的卧位。因此，用于骨质疏松性骨的生物材料是一个很好的选择。因此，这项工作旨在生产聚己内酯（PCL）和ALD基粉末，作为通过选择性激光烧结、压缩成型（CM）、溶剂浇铸（SC）等制造生物材料的原料。粉末是通过在ALD颗粒上涂覆PCL来制备的，薄膜是通过SC和CM技术制备的。通过扫描电子显微镜、能量色散X射线光谱、X射线衍射、傅里叶变换红外光谱和热分析对样品进行了表征。此外，通过紫外-可见光谱对药物释放进行了评估。结果表明，ALD颗粒被PCL成功包覆并应用于生物材料的生产，突出了其在骨质疏松症治疗中的潜力。

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