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首页> 外文期刊>Journal of Applied Polymer Science >Terpinen-4-ol liposomes-incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds
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Terpinen-4-ol liposomes-incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds

机译：Terpinen-4-Ol脂质体掺入的壳聚糖/聚环氧乙烷电纺纳米纤维膜改善了愈合皮肤伤口的外部微环境

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摘要

Chronic wounds are susceptible to infection and difficult to heal due to the complex healing process and terrible microenvironment. In order to overcome this problem, TOLs-CS/PEO nanofibrous film was successfully electrospun. The 6%(v/v) TOLs incorporation into CS/PEO nanofibrous film could improve the morphology and structure of nanofibers, weaken the interactions among macromolecules and rebalance the relationship between hydrophilicity and hydrophobicity of pore surface. Water vapor transmission rate and simulated tissue fluid absorption of films were optimized to reach 2193 g m(-2)d(-1)and 1676% so that to obtain the excellent moisture retention. The Young's modulus and elongation at break of films in wet state were 114.69 kPa and 72.04%, respectively, causing the mechanical characteristics similar to human skin. The film could effectively block more than 98% of bacteria and inhibit bacteria growth besides possessing procoagulant property and suitable biodegradability. These findings demonstrate that TOLs-CS/PEO nanofibrous film can construct a microenvironment suitable for wound healing.
机译：慢性伤口易受感染，愈合过程复杂，微环境恶劣，难以愈合。为了克服这一问题，成功地制备了TOLs-CS/PEO纳米纤维膜。将6%（v/v）的TOLs掺入CS/PEO纳米纤维膜中，可以改善纳米纤维的形态和结构，减弱大分子之间的相互作用，重新平衡孔表面亲水性和疏水性之间的关系。优化薄膜的水蒸气透过率和模拟组织液吸收率，使其达到2193 g m（-2）d（-1）和1676%，从而获得优异的保湿性。湿态薄膜的杨氏模量和断裂伸长率分别为114.69kPa和72.04%，导致其力学特性与人体皮肤相似。该膜除具有促凝性和适宜的生物降解性外，还能有效阻隔98%以上的细菌，抑制细菌生长。这些发现表明，TOLs-CS/PEO纳米纤维膜可以构建适合伤口愈合的微环境。

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