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首页> 外文期刊>Journal of Chemical Education >Integrating Natural Product Chemistry Workflows into Medicinal Chemistry Laboratory Training: Building the PRISM Library and Cultivating Independent Research
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Integrating Natural Product Chemistry Workflows into Medicinal Chemistry Laboratory Training: Building the PRISM Library and Cultivating Independent Research

机译：将天然产品化学工作流集成到药用化学实验室培训：建立棱镜图书馆并培养独立研究

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摘要

Chemical screening libraries often feature natural product extracts (NPEs) due to the intriguing biological activities they possess and the structural diversity found in their individual components. A research project originally designed to create an extract library of every specimen in the University of Rhode Island (URI) Heber W. Youngken Jr. Medicinal Garden soon turned into a laboratory-based teaching project in which upper-division undergraduate students generated and analyzed extracts in an academic minisemester project. Additionally, motivated upper-division undergraduates carried out independent research isolating biologically active molecules. Hands-on laboratory activities enhanced students' knowledge of methodologies and workflows associated with extract analysis and biological evaluation of botanical extracts. The synergy of the laboratory course with the independent study contributed to workforce preparation and library generation.
机译：化学筛选文库通常以天然产物提取物（NPE）为特征，这是因为它们具有有趣的生物活性，并且在各自的组分中发现了结构多样性。最初设计用于创建罗德岛大学（URI）Heb.W.Yungkon小药园的每一个标本的提取库的研究项目很快变成了一个基于实验室的教学项目，其中上师本科生在学术迷你项目中生成和分析提取。此外，积极上进的本科生进行了分离生物活性分子的独立研究。动手实验室活动增强了学生对提取物分析和植物提取物生物学评估相关方法和工作流程的了解。实验室课程与独立研究的协同作用有助于劳动力准备和图书馆建设。

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  • 来源
    《Journal of Chemical Education》 |2021年第2期|共6页
  • 作者

    Riley D. Kirk; Marina A. Carro; Christine Wu; Mohamad Jamal Aldine; Alex M. Wharton; Danielle G. Goldstein; Margaret E. Rosario; Gina M. Gallucci; Yiwen Zhao; Elizabeth Leibovitz; Matthew J. Bertin;

  • 作者单位

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

    Department of Biomedical and Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston Rhode Island 02881 United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

    Upper-Division Undergraduate; Laboratory Instruction; Hands-On Learning/Manipulatives; Natural Products; Medicinal Chemistry;

    机译：大分段本科;实验室教学;实践学习/操纵;天然产品;药用化学;

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