Characterization of a nitric oxide (NO) donor molecule and cerium oxide nanoparticle (CNP) interactions and their synergistic antimicrobial potential for biomedical applications

Estes Lori M.; Singha Priyadarshini; Singh Sushant; Sakthivel Tamil S.; Garren Mark; Devine Ryan; Brisbois Elizabeth J.; Seal Sudipta; Handa Hitesh

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Characterization of a nitric oxide (NO) donor molecule and cerium oxide nanoparticle (CNP) interactions and their synergistic antimicrobial potential for biomedical applications

机译：一氧化氮（NO）供体分子和氧化铈纳米粒子（CNP）相互作用的表征及其生物医学应用的协同抗微生物潜力

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Hypothesis: Broad-spectrum antimicrobials are needed to mitigate the complicated nature of antibiotic resistant infections. It is imperative to formulate new antimicrobials by combining agents with different mechanisms and broader microbial targets. A combined antimicrobial solution could be a highly critical step towards developing a strategy to prevent polymicrobial infections. Herein, we have investigated the interaction and antimicrobial potential of a solution that contains cerium oxide nanoparticles (CNP) and a nitric oxide (NO) donor, S-nitroso-N-acetylpenicillamine (SNAP). It is hypothesized that these two agents induce synergistic effects and would provide broad antimicrobial effects since CNP is known to be an effective antifungal agent while NO released by SNAP is known to be a potent bactericidal agent.

机译：假设：需要广谱抗生素来缓解抗生素耐药性感染的复杂性质。通过将不同机制的药物和更广泛的微生物靶点结合起来，制备新的抗菌剂势在必行。联合使用抗菌剂可能是制定预防多微生物感染战略的关键一步。在此，我们研究了含有氧化铈纳米颗粒（CNP）和一氧化氮（NO）供体S-亚硝基-N-乙酰青霉胺（SNAP）的溶液的相互作用和抗菌潜力。由于CNP是一种有效的抗真菌剂，而SNAP释放的NO是一种有效的杀菌剂，因此假设这两种药物诱导协同效应，并将提供广泛的抗菌效果。

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来源
《Journal of Colloid and Interface Science》 |2021年第1期|共15页
作者
Estes Lori M.; Singha Priyadarshini; Singh Sushant; Sakthivel Tamil S.; Garren Mark; Devine Ryan; Brisbois Elizabeth J.; Seal Sudipta; Handa Hitesh;
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作者单位

Univ Georgia Coll Engn Sch Chem Mat &

Biomed Engn 220 Riverbend Rd Athens GA 30602 USA;

Univ Georgia Coll Engn Sch Chem Mat &

Biomed Engn 220 Riverbend Rd Athens GA 30602 USA;

Univ Cent Florida Dept Mat Sci &

Engn Orlando FL 32816 USA;

Univ Cent Florida Dept Mat Sci &

Engn Orlando FL 32816 USA;

Univ Georgia Coll Engn Sch Chem Mat &

Biomed Engn 220 Riverbend Rd Athens GA 30602 USA;

Univ Georgia Coll Engn Sch Chem Mat &

Biomed Engn 220 Riverbend Rd Athens GA 30602 USA;

Univ Georgia Coll Engn Sch Chem Mat &

Biomed Engn 220 Riverbend Rd Athens GA 30602 USA;

Univ Cent Florida Dept Mat Sci &

Engn Orlando FL 32816 USA;

Univ Georgia Coll Engn Sch Chem Mat &

Biomed Engn 220 Riverbend Rd Athens GA 30602 USA;

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原文格式 PDF
正文语种 eng
中图分类表面现象的物理化学;胶体化学（分散体系的物理化学）;
关键词
Nitric oxide; Antimicrobial; Cerium oxide nanoparticle; Nanoceria; Antifungal; Bactericidal; Infection;

机译：一氧化氮;抗微生物;氧化铈纳米粒子;纳米细胞;抗真菌;杀菌剂;感染;

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Characterization of a nitric oxide (NO) donor molecule and cerium oxide nanoparticle (CNP) interactions and their synergistic antimicrobial potential for biomedical applications

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