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首页> 外文期刊>Journal of nanoscience and nanotechnology >Effect of Composite Nanoparticle CeO2 on Myocardial Ischemic Re-Infusion of Cardio Myocyte Apoptosis in Mouse
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Effect of Composite Nanoparticle CeO2 on Myocardial Ischemic Re-Infusion of Cardio Myocyte Apoptosis in Mouse

机译:复合纳米粒子CEO2对小鼠心肌缺血性凋亡的心肌缺血再输注的影响

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摘要

The myocardial I/R damage is very complicated. Apoptosis is considered to its a critical mechanism. During the cardiac muscle I/R process, oxygen-free radicals play a pivotal role. Arrhythmias, as well as enlargement of the area of myocardial infarction after cardiac muscle I/R process,are caused by adequate blast generated O2- ion free radicals. During the ischemia-reperfusion process, a large amount of O2- ion free radicals destroyed the cell structure, and it undergoes lipid peroxidation with unsaturated fatty acids that contain a large number ofphospholipids in the cell membrane, causing membrane proteins such as ion channels and enzymes on the cell membrane. The activity of cell is reduced, which affects the function of cell membrane and organelle membrane, destroys its integrity and reduces fluidity.We observed the effects of ceriumdioxide nanoparticles on glutathione peroxidase as well as superoxide dismutase, also propionate in myocardial tissue of I/R injury in the mouse. Its effects of malondialdehyde and apoptosis were explored to see its protective effect and to provide more preventive measures for ischemia-reperfusioninjury.
机译:心肌I/R损伤非常复杂。细胞凋亡被认为是其重要机制。在心肌I/R过程中,氧自由基起着关键作用。心律失常,以及心肌I/R过程后心肌梗死面积的扩大,是由充足的冲击波产生的氧离子自由基引起的。在缺血再灌注过程中,大量O2-离子自由基破坏细胞结构,并与细胞膜中含有大量磷脂的不饱和脂肪酸发生脂质过氧化,导致细胞膜上的离子通道和酶等膜蛋白。细胞活性降低,影响细胞膜和细胞器膜的功能,破坏其完整性,降低流动性。我们观察了氧化铈纳米颗粒对I/R损伤小鼠心肌组织中谷胱甘肽过氧化物酶和超氧化物歧化酶以及丙酸盐的影响。探讨其对丙二醛和细胞凋亡的影响,以观察其保护作用,并为缺血再灌注损伤提供更多的预防措施。

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