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首页> 外文期刊>Journal of Molecular Biology >Biochemical Timekeeping Via Reentrant Phase Transitions
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Biochemical Timekeeping Via Reentrant Phase Transitions

机译：通过重入阶段过渡的生化计时

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Appreciation for the role of liquid-liquid phase separation in the functional organization of cellular matter has exploded in recent years. More recently there has been a growing effort to understand the principles of heterotypic phase separation, the demixing of multiple proteins and nucleic acids into a single functional condensate. A phase transition is termed reentrant if it involves the transformation of a system from one state into a macroscopically similar or identical state via at least two phase transitions elicited by variation of a single parameter. Reentrant liquid-liquid phase separation can occur when the condensation of one species is tuned by another. Reentrant phase transitions have been modeled in vitro using protein and RNA mixtures. These biochemical studies reveal two features of reentrant phase separation that are likely important to functional cellular condensates: (1) the ability to generate condensates with layered functional topologies, and (2) the ability to generate condensates whose composition and duration are self-limiting to enable a form of biochemical timekeeping. We relate these biochemical studies to potential cellular examples and discuss how layered topologies and self-regulation may impact key biological processes. (C) 2020 Elsevier Ltd. All rights reserved.
机译：近年来，人们对液-液相分离在细胞物质的功能组织中所起作用的认识迅速增加。最近，人们越来越努力地理解异型相分离的原理，即将多种蛋白质和核酸分离成单一功能的缩合物。如果相变涉及通过单个参数变化引起的至少两个相变将系统从一种状态转换为宏观相似或相同的状态，则称为可重入相变。当一种物质的冷凝被另一种物质调节时，会发生重入式液-液相分离。利用蛋白质和RNA混合物在体外模拟了重入相变。这些生物化学研究揭示了重入相分离的两个特征，这两个特征可能对功能性细胞凝聚体很重要：（1）生成具有分层功能拓扑结构的凝聚体的能力，以及（2）生成成分和持续时间自限的凝聚体的能力，以实现某种形式的生物化学计时。我们将这些生化研究与潜在的细胞实例联系起来，并讨论分层拓扑结构和自我调节如何影响关键的生物过程。（C） 2020爱思唯尔有限公司版权所有。

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