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首页> 外文期刊>Journal of Neurophysiology >Pavlovian eyeblink conditioning is severely impaired in tottering mice.
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Pavlovian eyeblink conditioning is severely impaired in tottering mice.

机译：Pavlovian的眼睛掩蔽条件在缠扰老鼠中受到严重受损。

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Cacna1a encodes the pore-forming α_(1A)subunit of Ca_(V)2.1 voltage-dependent calcium channels, which regulate neuronal excitability and synaptic transmission. Purkinje cells in the cortex of cerebellum abundantly express these Ca_(V)2.1 channels. Here, we show that homozygous tottering (tg) mice, which carry a loss-of-function Cacna1a mutation, exhibit severely impaired learning in Pavlovian eyeblink conditioning, which is a cerebellar-dependent learning task. Performance of reflexive eyeblinks is unaffected in tg mice. Transient seizure activity in tg mice further corrupted the amplitude of eyeblink conditioned responses. Our results indicate that normal calcium homeostasis is imperative for cerebellar learning and that the oscillatory state of the brain can affect the expression thereof. NEW & NOTEWORTHY In this study, we confirm the importance of normal calcium homeostasis in neurons for learning and memory formation. In a mouse model with a mutation in an essential calcium channel that is abundantly expressed in the cerebellum, we found severely impaired learning in eyeblink conditioning. Eyeblink conditioning is a cerebellar-dependent learning task. During brief periods of brain-wide oscillatory activity, as a result of the mutation, the expression of conditioned eyeblinks was even further disrupted.
机译：Cacna1a编码Ca_V（V）2.1电压依赖性钙通道的成孔α1A亚单位，调节神经元兴奋性和突触传递。小脑皮质的浦肯野细胞大量表达这些Ca_V（2.1）通道。在这里，我们发现纯合子蹒跚（tg）小鼠携带功能缺失的Cacna1a突变，在巴甫洛夫眼球连接条件反射中表现出严重的学习障碍，这是一种依赖小脑的学习任务。tg小鼠的反射性眼球连接功能不受影响。tg小鼠短暂的癫痫发作活动进一步破坏了眼球连接条件性反应的振幅。我们的结果表明，正常的钙稳态对小脑学习至关重要，大脑的振荡状态可以影响其表达。新的和值得注意的是，在这项研究中，我们确认了神经元正常钙稳态对学习和记忆形成的重要性。在一个在小脑中大量表达的必需钙通道发生突变的小鼠模型中，我们发现在眼球链接条件反射中学习能力严重受损。眼球链接调节是一项依赖小脑的学习任务。在短暂的全脑振荡活动期间，由于基因突变，条件性眼链的表达甚至被进一步破坏。

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