Catalytic Reactions and Energy Conservation in the Cytochrome bc(1) and b(6)f Complexes of Energy-Transducing Membranes

Sarewicz Marcin; Pintscher Sebastian; Pietras Rafal; Borek Arkadiusz; Bujnowicz Lukasz; Hanke Guy; Cramer William A.; Finazzi Giovanni; Osyczka Artur

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Catalytic Reactions and Energy Conservation in the Cytochrome bc(1) and b(6)f Complexes of Energy-Transducing Membranes

机译：细胞色素BC（1）和B（6）F复合物的催化反应和节能能量转换膜

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This review focuses on key components of respiratory and photosynthetic energy-transduction systems: the cytochrome bc(1) and b(6)f (Cytbc(1)/b(6)f) membranous multisubunit homodimeric complexes. These remarkable molecular machines catalyze electron transfer from membranous quinones to water-soluble electron carriers (such as cytochromes c or plastocyanin), coupling electron flow to proton translocation across the energy-transducing membrane and contributing to the generation of a transmembrane electrochemical potential gradient, which powers cellular metabolism in the majority of living organisms. Cytsbc(1)/b(6)f share many similarities but also have significant differences. While decades of research have provided extensive knowledge on these enzymes, several important aspects of their molecular mechanisms remain to be elucidated. We summarize a broad range of structural, mechanistic, and physiological aspects required for function of Cytbc(1)/b(6)f, combining textbook fundamentals with new intriguing concepts that have emerged from more recent studies. The discussion covers but is not limited to (i) mechanisms of energy-conserving bifurcation of electron pathway and energy-wasting superoxide generation at the quinol oxidation site, (ii) the mechanism by which semiquinone is stabilized at the quinone reduction site, (iii) interactions with substrates and specific inhibitors, (iv) intermonomer electron transfer and the role of a dimeric complex, and (v) higher levels of organization and regulation that involve Cytsbc(1)/b(6)f. In addressing these topics, we point out existing uncertainties and controversies, which, as suggested, will drive further research in this field.

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《Chemical Reviews》 |2021年第4期|共89页
作者
Sarewicz Marcin; Pintscher Sebastian; Pietras Rafal; Borek Arkadiusz; Bujnowicz Lukasz; Hanke Guy; Cramer William A.; Finazzi Giovanni; Osyczka Artur;
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作者单位

Jagiellonian Univ Fac Biochem Biophys &

Biotechnol Dept Mol Biophys PL-30387 Krakow Poland;

Jagiellonian Univ Fac Biochem Biophys &

Biotechnol Dept Mol Biophys PL-30387 Krakow Poland;

Jagiellonian Univ Fac Biochem Biophys &

Biotechnol Dept Mol Biophys PL-30387 Krakow Poland;

Jagiellonian Univ Fac Biochem Biophys &

Biotechnol Dept Mol Biophys PL-30387 Krakow Poland;

Jagiellonian Univ Fac Biochem Biophys &

Biotechnol Dept Mol Biophys PL-30387 Krakow Poland;

Queen Mary Univ London Sch Biol &

Chem Sci London E1 4NS England;

Purdue Univ Dept Biol Sci W Lafayette IN 47907 USA;

Univ Grenoble Alpes Commissariat Energie Atom &

Energies Alternat Inst Natl Rech Agr Lab Physiol Cellulaire &

Vegetale CNRS F-38054 Grenoble France;

Jagiellonian Univ Fac Biochem Biophys &

Biotechnol Dept Mol Biophys PL-30387 Krakow Poland;

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正文语种 eng
中图分类化学;
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机译：细胞色素BC1和能量转换膜的B6F复合物中的催化反应和节能
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机译：细胞色素B-563在细胞色素B / F复合物和类囊体膜中的动力学和光谱研究

Catalytic Reactions and Energy Conservation in the Cytochrome bc(1) and b(6)f Complexes of Energy-Transducing Membranes

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