Avoiding Drug Resistance in HIV Reverse Transcriptase

Maria E.  Cilento; Karen A.  Kirby; Stefan G.  Sarafianos

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Avoiding Drug Resistance in HIV Reverse Transcriptase

机译：避免HIV逆转录酶中的耐药性

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HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of HIV and has been a key target of anti-HIV drug development efforts. Because of the high genetic diversity of the virus, mutations in RT can impart resistance to various RT inhibitors. As the prevalence of drug resistance mutations is on the rise, it is necessary to design strategies that will lead to drugs less susceptible to resistance. Here we provide an in-depth review of HIV reverse transcriptase, current RT inhibitors, novel RT inhibitors, and mechanisms of drug resistance. We also present novel strategies that can be useful to overcome RT’s ability to escape therapies through drug resistance. While resistance may not be completely avoidable, designing drugs based on the strategies and principles discussed in this review could decrease the prevalence of drug resistance.

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来源
《Chemical Reviews》 |2021年第6期|共26页
作者
Maria E. Cilento; Karen A. Kirby; Stefan G. Sarafianos;
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Laboratory of Biochemical Pharmacology Department of Pediatrics Emory University School of Medicine;

Laboratory of Biochemical Pharmacology Department of Pediatrics Emory University School of Medicine;

Laboratory of Biochemical Pharmacology Department of Pediatrics Emory University School of Medicine;

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正文语种 eng
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2. Resistance evolutionary pathway analysis of HIV-1 CRF₀7BC reverse transcriptase [J] . 李臻鹏中国医学文摘：内科学分册（英文版） . 2014,第002期
3. Synthesis and anti-HIV-1 activity evaluation of N-l-alkyl-5-halogeno-6- alkylamino uracils as novel non-nucleoside HIV-I reverse transcriptase inhibitors [J] . Han Yan, Xiao-Wei Wang, Ying Guo, 中国药学：英文版 . 2011,第002期
4. Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors [J] . XuH.-T., Colby-GerminarioS.P., OliveiraM., Antimicrobial agents and chemotherapy. . 2014,第8期

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5. Development and evaluation of a national reference panel of HIV-1 protease and reverse transcriptase drug-resistance mutations for HIV-1 genotypic resistance assays in China. [J] . Xu S, Li J, Bao Z, Molecular diagnosis & therapy . 2010,第1期

机译：中国HIV-1蛋白酶和逆转录酶耐药突变国家参考小组的开发和评估。
6. Interactions of different drug resistance mutations in HIV Reverse Transcriptase in defining patterns of drug resistance [J] . Mark A Wainberg Retrovirology . 2011,第S2期

机译：HIV逆转录酶中不同耐药突变的相互作用在确定耐药模式中的作用
7. Predicting HIV-1 Protease and Reverse Transcriptase Drug Resistance Using Fuzzy Cognitive Maps [C] . Isel Grau, Gonzalo Napoles, Maria M. Garcia Iberoamerican congress on pattern recognition . 2013

机译：使用模糊认知图预测HIV-1蛋白酶和逆转录酶的耐药性
8. HIV-1 Reverse Transcriptase: Determinants and Impact of the Translocational Equilibrium with Implications for Drug Resistance [D] . Scarth, Brian James 2011

机译：HIV-1逆转录酶：易位性的决定因素和影响与耐药性的影响。
9. Effects of the W153L Substitution in HIV Reverse Transcriptase on Viral Replication and Drug Resistance to Multiple Categories of Reverse Transcriptase Inhibitors [O] . Hong-Tao Xu, Susan P. Colby-Germinario, Maureen Oliveira, 2014

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11. Guidance for Industry: Class II Special Controls Guidance Document: In Vitro HIV Drug Resistance Genotype Assay [R] . 2011

机译：工业指南：II类特殊控制指导文件：体外HIV耐药性基因型分析

Avoiding Drug Resistance in HIV Reverse Transcriptase

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