Serum proteins change shape of nanoparticle drug carriers

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Serum proteins change shape of nanoparticle drug carriers

机译：血清蛋白质纳米粒子药物载体的形状

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Nanoparticles are widely investigated as a tool to deliver therapeutic drugs.It was assumed that these nano-sized carriers could circulate around the bloodstream and stay unnoticed by the body's defence mechanisms.But it is now known that most particles are quickly covered with blood proteins,covering the often carefully designed nanoparticle surface.Researchers have so far focused on the thickness of the protein corona and the type of proteins absorbed,as these factors can influence whether the nanoparticle is detected by the immune system.Now a team led by Martina Stenzel at UNSW Sydney has shown that adsorbed proteins can deform nanoparticles(Cao C,Zhang L,Kent B.,Wong S.,Garvey C.J.,Stenzel M.H.Angew.Chem.Int.Ed.2021,60,10 342-9).

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《Chemistry in Australia》 |2021年第junaaauga期|共1页
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正文语种 eng
中图分类化学;化学工业;
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机译：基于Au纳米粒子的多柔比星载体 - 形状和金药物接头对载体毒性和治疗性能的影响
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12. The Effect of Cage Shape on Nanoparticle-Based Drug Carriers: Anticancer Drug Release and Efficacy via Receptor Blockade Using Dextran-Coated Iron Oxide Nanocages [O] . Sham Rampersaud, Justin Fang, Zengyan Wei, 2016

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机译：开发针对癌症治疗的药物靶向方法：药物载体 - 蛋白质缀合物。

Serum proteins change shape of nanoparticle drug carriers

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