Maintenance avelumab for metastatic urothelial cancer: a new standard of care

Erck Alisa; Aragon-Ching Jeanny B.

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Maintenance avelumab for metastatic urothelial cancer: a new standard of care

机译：维护Avelumab用于转移性尿路上皮癌：新的护理标准

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摘要

The Javelin Bladder 100 trial was the first trial to establish the role of switch maintenance therapy in patients with metastatic urothelial cancer using avelumab, a PD-L1 inhibitor, for patients who achieve complete response, partial response, or stable disease to standard chemotherapy of 4-6 cycles with gemcitabine and cisplatin or carboplatin. Improvement in parameters of overall survival in both the overall population and the PD-L1 positive population was seen and has led to the US FDA approval of avelumab as maintenance therapy for metastatic urothelial cancer. This manuscript further discusses the highlights of the study, patient population, and considerations regarding choice of therapy for maintenance avelumab.

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《Cancer biology & therapy》 |2020年第12期|共2页
作者
Erck Alisa; Aragon-Ching Jeanny B.;
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作者单位

Univ Virginia Sch Med Dept Med Charlottesville VA 22908 USA;

GU Med Oncol Fairfax VA USA;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Metastatic urothelial cancer; avelumab; immunotherapy; maintenance therapy;

机译：转移性尿路上皮癌;Avelumab;免疫疗法;维护治疗;

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Maintenance avelumab for metastatic urothelial cancer: a new standard of care

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