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首页> 外文期刊>Cancer biology & therapy >Overexpression of family with sequence similarity 134, member B (FAM134B) in colon cancers and its tumor suppressive properties in vitro
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Overexpression of family with sequence similarity 134, member B (FAM134B) in colon cancers and its tumor suppressive properties in vitro

机译：具有序列相似性134，成员B（FAM134B）的家庭过度表达在结肠癌及其肿瘤抑制性质体外

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摘要

This study aims to investigate the overexpression-induced properties of tumor suppressorFAM134B(family with sequence similarity 134, member B) in colon cancer, examine the potential gene regulators ofFAM134Bexpression and its impact on mitochondrial function.FAM134Bwas overexpressed in colon cancer and non-neoplastic colonic epithelial cells. Various cell-based assays including apoptosis, cell cycle, cell proliferation, clonogenic, extracellular flux and wound healing assays were performed. Western blot analysis was used to confirm and identify potential interacting partners ofFAM134B in vitro. Immunohistochemistry and qPCR were employed to determine the expressions of MIF andFAM134B, respectively, on 63 patients with colorectal carcinoma. Results showed thatFAM134Bis involved in the cell cycle and mitochondrial function of colon cancer. Overexpression ofFAM134Bwas coupled with increased expression levels of APC, p53, and MIF. Increased expression of both APC and p53 further validates the potential role of tumor suppressorFAM134Bin regulating cancer progression through the WNT/ss-catenin signaling pathway. In approximately 70% of the patients with colorectal cancer,FAM134Bdownregulation was correlated with MIF protein overexpression while the remaining 30% showed concurrent expression ofFAM134Band MIF (P= .045). High expression of MIF coupled with low expression ofFAM134Bis associated with microsatellite instability status in colorectal carcinomas (P= .049).FAM134Bmay exert its tumor suppressive function through affecting cell cycle, mitochondrial function via potentially interacting with MIF and p53.
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