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首页> 外文期刊>Cancer biology & therapy >Tumor associated neutrophils promote the metastasis of pancreatic ductal adenocarcinoma
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Tumor associated neutrophils promote the metastasis of pancreatic ductal adenocarcinoma

机译：肿瘤相关中性粒细胞促进胰腺导管腺癌的转移

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摘要

The aim of this study was to investigate the role of tumor-associated neutrophils (TANs) in the metastasis of pancreatic ductal adenocarcinoma (PDAC), to explore the regulation of TANs, and to determine the mechanisms governing the metastasis of PDAC. The correlation between neutrophils and the patient's clinical pathological data was first evaluated. Then, the effects of neutrophils on the invasion of PDAC were analyzed using a combination of conditioned media, direct and indirect coculture of human peripheral blood neutrophils, and PDAC cell lines (Panc-1, MiaPaCa-2 and AsPC-1). The cytokines secreted by neutrophils were detected through ELISA. TAN density was significantly correlated with poor metastasis-free survival (P< .05). Through coculture, it was found that the effect of neutrophils on pancreatic cancer cells was dependent on concentration, and a high concentration of neutrophils showed a lethal effect, while a low concentration of neutrophils primarily promoted the migration ability of cancer cells. The results of the wound-healing assay, the Transwell invasion assay, and laser confocal microscopy confirmed the promoting effect and indicated that the effect of neutrophils toward cancer cells may function indirectly by releasing a series of cytokines. The results of ELISA show that this effect may be achieved through the secretion of a large amount of TNF-alpha and TGF-beta 1 by neutrophils. Our study indicated that neutrophils may increase the metastasis of PDAC by releasing a series of cell cytokines, such as TNF-alpha and TGF-beta 1.
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  • 来源
    《Cancer biology & therapy》 |2020年第12期|共9页
  • 作者

    Lianyuan Tao; Gang Li; Ming Tao; Dianrong Xiu; Chunhui Yuan; Zhaolai Ma; Bin Jiang;

  • 作者单位

    Peking Univ Third Hosp Dept Gen Surg Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Gen Surg Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Gen Surg Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Gen Surg Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Gen Surg Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Gen Surg Beijing 100191 Peoples R China;

    Peking Univ Third Hosp Dept Gen Surg Beijing 100191 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    PDAC; neutrophils; metastasis; TNF-alpha; TGF-B1;

    机译：PDAC;中性粒细胞;转移;TNF-alpha;TGF-B1;

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