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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Non-receptor type, proline-rich protein tyrosine kinase 2 (Pyk2) is a possible therapeutic target for Kawasaki disease
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Non-receptor type, proline-rich protein tyrosine kinase 2 (Pyk2) is a possible therapeutic target for Kawasaki disease

机译：非受体类型，富含富含蛋白酪氨酸激酶2（Pyk2）是川崎病的可能治疗靶标

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摘要

Abstract Kawasaki disease (KD) is a paediatric vasculitis whose pathogenesis remains unclear. Based on experimental studies using a mouse model for KD, we report here that proline-rich protein tyrosine kinase 2 (Pyk2) plays a critical role in the onset of KD-like murine vasculitis. The mouse model for KD was prepared by administrating a Candida albicans water-soluble fraction (CAWS). Unlike CAWS-treated WT mice, CAWS-treated Pyk2-Knockout (Pyk2-KO) mice did not develop apparent vasculitis. A sustained increase in MIG/CXCL9 and IP-10/CXCL10, both of which have potent angiostatic activity, was observed in CAWS-treated Pyk2-KO mice. CAWS-induced activation of STAT3, which negatively regulates the expression of these chemokines, was also attenuated in macrophages derived from Pyk2-KO mice. The present study suggests that defects in Pyk2 suppress KD-like experimental vasculitis, presumably through CXCL9- and CXCL10-dependent interference with neo-angiogenesis. Since Pyk2-KO mice show no life-threatening phenotype, Pyk2 may be a promising therapeutic molecular target for KD. Highlights ? Pyk2 plays a crucial role in the onset of Kawasaki disease-like murine vasculitis. ? Pyk2 deficiency might attenuate neo-angiogenesis involved in developing vasculitis. ? Pyk2 could be a molecular target to treat Kawasaki disease.
机译：None

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    Chinatsu Suzuki; Akihiro Nakamura; Noriko Miura; Kuniyoshi Fukai; Naohito Ohno; Tomoyo Yahata; Akiko Okamoto-Hamaoka; Maiko Fujii; Ayako Yoshioka; Yuki Kuchitsu; Kazuyuki Ikeda; Kenji Hamaoka;

  • 作者单位

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Laboratory for Immunopharmacology of Microbial Products School of Pharmacy Tokyo University of;

    Department of Cardiovascular Medicine Graduate School of Medical Science Kyoto Prefectural;

    Laboratory for Immunopharmacology of Microbial Products School of Pharmacy Tokyo University of;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

    Department of Pediatric Cardiology and Nephrology Graduate School of Medical Science Kyoto;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    Kawasaki disease; Vasculitis; Pyk2; IP-10;

    机译：川崎病;血管炎;PYK2;IP-10;

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