The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases

Yin Jinghua; Zhang Jian; Lu Qianjin

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The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases

机译：基础亮氨酸拉链转录因子E4bp4在免疫系统和免疫介导的疾病中的作用

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Basic leucine zipper transcription factor E4BP4 (also known as NFIL3) has been implicated in the molecular and cellular mechanisms of functions and activities in mammals. The interactions between E4BP4 and major regulators of cellular processes have triggered significant interest in the roles of E4BP4 in the pathogenesis of certain chronic diseases. Indeed, novel discoveries have been emerging to illustrate the involvement of E4BP4 in multiple disorders. It is recognized that E4BP4 is extensively involved in some immune-mediated diseases, but the mechanisms of E4BP4 involvement in these complex diseases remain poorly defined. Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies. (C) 2017 Published by Elsevier Inc.

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来源
《Clinical immunology: The official journal of the Clinical Immunology Society》 |2017年第2017期|共6页
作者
Yin Jinghua; Zhang Jian; Lu Qianjin;
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作者单位

Cent S Univ Dept Dermatol Hunan Key Lab Med Epigen Xiangya Hosp 2 139 Renmin Rd Changsha;

Ohio State Univ Dept Microbial Infect &

Immun 460 West 12th Ave Columbus OH 43210 USA;

Cent S Univ Dept Dermatol Hunan Key Lab Med Epigen Xiangya Hosp 2 139 Renmin Rd Changsha;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
E4BP4; Mouse models; Cellular processes; Immune-mediated-diseases;

机译：E4bp4;小鼠模型;细胞过程;免疫介导的疾病;

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3. Genome-wide Expansion and Expression Divergence of the Basic Leucine Zipper Transcription Factors in Higher Plants with an Emphasis on Sorghum [J] . Jizhou Wang, Junxia Zhou, Baolan Zhang, 植物学报：英文版 . 2011,第003期
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The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases

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