IL-10-producing regulatory B cells (B10 cells), IL-17+ T cells and autoantibodies in systemic sclerosis

Athanasios Mavropoulos; Christos Liaskos; Theodora Simopoulou; Dimitrios P. Bogdanos; Lazaros I. Sakkas

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IL-10-producing regulatory B cells (B10 cells), IL-17+ T cells and autoantibodies in systemic sclerosis

机译：IL-10产生调节B细胞（B10细胞），IL-17 + T细胞和系统性硬化症中的自身抗体

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Abstract We aimed to analyze IL-10+ Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17+ and IFNγ+ T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc positive for anti-Topo I or anti-Cen autoAbs, and 12 healthy controls (HC) were studied by flow cytometry. IL-17+ and IFNγ+ T cells were also studied. B10 cells did not correlate with anti-Topo I or anti-Cen Ab levels but were inversely correlated with IL-17+ CD3+ cells and IFNγ+ CD3+ cells. IL-17+ CD3+ cells did not correlate with autoAb levels, but IFN-γ+ CD3+ cells were inversely correlated with anti-Topo I levels. In conclusion, in SSc, B10 cells did not correlate with SSc-specific autoAbs and exhibited an inverse correlation with IL-17+ T cells and IFNγ+ T cells. Highlights ? B10 (IL-10-producing Bregs) are impaired in systemic sclerosis. ? B10 cells do not correlate with SSc-specific autoantibody levels. ? B10 cells inversely correlate with IL-17+ CD3+ cells in scleroderma. ? B10 cells inversely correlate with IFN-γ+ CD3+ cells in dcSSc but not in lcSSc. ? IFN-γ+ CD3+ cell percentages inversely correlate with anti-Topo I levels.

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来源
《Clinical immunology: The official journal of the Clinical Immunology Society》 |2017年第2017期|共7页
作者
Athanasios Mavropoulos; Christos Liaskos; Theodora Simopoulou; Dimitrios P. Bogdanos; Lazaros I. Sakkas;
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作者单位

Department of Rheumatology and Clinical Immunology Faculty of Medicine School of Health Sciences;

Department of Rheumatology and Clinical Immunology Faculty of Medicine School of Health Sciences;

Department of Rheumatology and Clinical Immunology Faculty of Medicine School of Health Sciences;

Department of Rheumatology and Clinical Immunology Faculty of Medicine School of Health Sciences;

Department of Rheumatology and Clinical Immunology Faculty of Medicine School of Health Sciences;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Autoimmunity; Autoantibody; B regulatory cells; Scleroderma; T cells;

机译：自身免疫;自身抗体;B调节细胞;硬皮病;T细胞;

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IL-10-producing regulatory B cells (B10 cells), IL-17+ T cells and autoantibodies in systemic sclerosis

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