IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis

Abhra Chandra Chowdhury; Smriti Chaurasia; Shravan Kumar Mishra; Amita Aggarwal; Ramnath Misra

首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis

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IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis

机译：产生NK和IFN-γ的IL-17和IFN-γ-T细胞优先在活性关节炎和未分化的脊椎炎患者的滑膜中扩增

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Abstract The IL-17/1L-23 axis is important in the pathogenesis of spondyloarthropathy. Innate cells produce IL-17 in addition to Th17 cells. We studied the frequencies of natural killer (NK) (total, CD56 bright , CD56 dim , perforin+ and granzyme+), NK-T, γδ-T, and IFN-γ+, IL-17+ NK and γδ-T cells in peripheral blood (PB) and synovial fluid (SF) of ReA/uSpA patients. PB from 45 patients and paired SF from 39 patients were studied, together with PB from 18 healthy controls (HC). The frequency of γδ-T cells was decreased (p bright NK cells were increased (p

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来源
《Clinical immunology: The official journal of the Clinical Immunology Society》 |2017年第2017期|共6页
作者
Abhra Chandra Chowdhury; Smriti Chaurasia; Shravan Kumar Mishra; Amita Aggarwal; Ramnath Misra;
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作者单位

Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences;

Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences;

Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences;

Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences;

Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Synovial fluid; Inflammation; Interleukin 17; Natural killer cells; Gamma Delta T cells;

机译：滑膜;炎症;白细胞介素17;天然杀伤细胞;γδt细胞;

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1. Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients [J] . WANG Jun-feng, GUAN Zhen-peng, ZHANG Shao-long, 中华医学杂志（英文版） . 2013,第002期
2. Effects of Tripchlorolide（T4）of Tripterygium Wilfordii Hook on the Production of Interleukin-6 by peripheral Blood Mononeuclear Cells and Synovial Cells of Rheumatoid Arthritis Patients [J] . 要庆平, 张乃峥中国医学科学杂志：英文版 . 1996,第001期
3. ADAMTS-8 Activity in Synovial Cells in Patients with Rheumatoid Arthritis [J] . Murat Baloğlu, Engin Deveci, Şenay Deveci 风湿病与自身免疫疾病期刊（英文） . 2020,第003期
4. CD4+ T cells from behcet patients produce high levels of IL-17 [J] . Wei Chi, Sheng Zhou, Peizeng Yang, 眼科学报（英文版） . 2011,第002期
5. CD4＋ T cells from behcet patients produce high levels of IL-17 [J] . Wei Chi, Sheng Zhou, Peizeng Yang, 眼科学报：英文版 . 2011,第002期
6. IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis [J] . Abhra Chandra Chowdhury, Smriti Chaurasia, Shravan Kumar Mishra, Clinical immunology: The official journal of the Clinical Immunology Society . 2017,第期

机译：产生NK和IFN-γ和IFN-γ优先在反应性关节炎患者的滑液中膨胀和初期的脊髓灰质炎
7. Recombinant Salmonella typhimurium outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce interleukin (IL)-17/IL-23 in patients with reactive arthritis and undifferentiated spondyloarthropathy [J] . Chaurasia S., Shasany A. K., Aggarwal A., Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2016,第2期

机译：重组鼠伤寒沙门氏菌外膜蛋白A被滑液CD8细胞识别并刺激滑液单核细胞产生反应性关节炎和未分化的脊椎骨关节炎的白介素（IL）-17 / IL-23
8. Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritis. [J] . Dulphy N, Rabian C, Douay C, International immunology. . 2002,第5期

机译：在HLA-B27相关反应性关节炎中，NK细胞受体表达可调节CD8 +滑液T细胞的功能。
9. Chapter 70 Comparison of Beta Variable Gene Usage of T Cell Receptor in Peripheral Blood and Synovial Fluid of Rheumatoid Arthritis Patients [C] . Jianwei Zhou, Cui Kong, Xiukui Wang, International symposium on IT in medicine and education . 2014

机译：第70章类风湿关节炎患者外周血和滑液中T细胞受体β可变基因用法的比较
10. An increase in the frequency of hprt mutant T lymphocytes in the peripheral blood, synovial fluid, and synovial tissue of rheumatoid arthritis patients. [D] . Cannons, Jennifer. 1997

机译：类风湿性关节炎患者外周血，滑液和滑膜组织中hprt突变T淋巴细胞的频率增加。
11. Recombinant Salmonella typhimurium outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce interleukin (IL)‐17/IL‐23 in patients with reactive arthritis and undifferentiated spondyloarthropathy [O] . S. Chaurasia, A. K. Shasany, A. Aggarwal, 2016

机译：关节液鼠伤寒沙门氏菌外膜蛋白A被滑液CD8细胞识别并刺激滑液单核细胞产生反应性关节炎和未分化型脊柱关节炎的白介素（IL）-17 / IL-23
12. Recombinant Salmonella typhimurium outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce interleukin (IL)-17/IL-23 in patients with reactive arthritis and undifferentiated spondyloart [O] . S. Chaurasia, A. K. Shasany, A. Aggarwal, 2016

机译：通过滑膜液CD8细胞识别重组沙门氏菌外膜蛋白A，并刺激在活性关节炎和未分化的脊柱型患者中产生白细胞介素（IL）-17 / IL-23的滑膜液（IL）-17 / IL-23
13. Differential Reactivity of Rheumatoid Synovial Cells and Serum Rheumatoid Factors to Human Immunoglobulin G Subclasses 1 and 3 and Their CH3 Domains in Rheumatoid Arthritis [R] . Robbins, D. L., Benisek, W. F., Benjamini, E., 1987

机译：类风湿关节炎细胞和血清类风湿因子对人免疫球蛋白G亚类1和3及其类风湿性关节炎CH3区的差异反应性

IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis

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