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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Assessment of female rats for studying episodic memory and its deficit associated with doxorubicin-induced chemobrain
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Assessment of female rats for studying episodic memory and its deficit associated with doxorubicin-induced chemobrain

机译：雌性大鼠研究情节记忆的雌性大鼠及其与多柔比蛋白诱导的化学素相关的缺陷

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To Editor In neurocognitive studies, usually male rats are preferred over female rats to preclude the possible influence of the oestrus cycle. Also, the reports suggests that male rats learn quicker in complex maze tasks, which make them the logically sound choice for such studies. But the results of preclinical studies in a cognitive condition like chemobrain using healthy male rats have been mixed and ambiguous, generating questions about the validity of the usage of male animals for this condition. One of the reasons for the ambiguous results obtained using the males rats could be due to the fact that chemobrain, a term used to refer cognitive deficits that are usually observed clinically in long-term breast cancer survivors (female population) who have undergone chemotherapy,4 is a gender-specific neurocognitive condition. Hence, for chemobrain, it is more appropriate to have a behavioural animal model using female rats (regardless of oestrus cycle interference) for assessing the cognitive deficits induced by chemotherapeutic agents. To address this issue, in the current study, we have assessed the role of gender difference in a dox-orubicin (DOX)-induced chemobrain-like condition with possible episodic memory deficits in a validated novel object recognition task (NORT). The study was conducted in both male and female Wistar rats to assess the extent and formation of episodic memory in NORT and also to develop a valid female rat model for the chemofog. In addition, the potential of donepezil in reversing time delay-induced episodic memory deficit in both male and female rats at various inter-trial intervals (ITI) was evaluated.
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