Analysis of very important pharmacogene variants in the Tibetan population from China

Rong Hao; Dong Hongzhi; He Xue; Yuan Dongya; Bai Mei; Wang Li; Liu Tao; He Yongjun; Zheng Jianwen; Wang Yuhe; Jin Tianbo

首页> 外文期刊>Clinical and experimental pharmacology & physiology >Analysis of very important pharmacogene variants in the Tibetan population from China

【24h】

Analysis of very important pharmacogene variants in the Tibetan population from China

机译：中国藏族人口中非常重要的药物转基因分析

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Personalized medicine, the treatment best suited for an individual, is a hot field of clinical research in the world. Many recent studies have shown that genetic variations have a great influence on the treatment. This study aimed to identify the distribution differences of very important pharmacogene (VIP) variants between the Tibetan population and the other 26 populations from the 1000 Genomes project. Based on the PharmGKB database, we successfully genotyped 50 VIP variants located in 27 genes in the Tibetan population. We also compared the genotype frequencies of VIP variants between Tibetan population and the other 26 populations. Without adjustment, the Chi-square test showed that the only significant variant between Tibetans and every other group was rs1801159 in dihydropyrimidine dehydrogenase (DPYD), followed by rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs1051296 in solute carrier family 19 member 1 (SLC19A1). After Bonferroni's multiple adjustments, the genotype frequencies distribution of DPYD rs1801159 was found to be different in Tibetans compared to the other 26 groups, apart from ACB and ASW. Moreover, genetic structure/F-statistics (Fst) analysis and the phylogenetic tree illustrated that Tibetans had a closer affinity with CDX, CHB, CHS, JPT and KHV. Our data will complement pharmacogenomics information of the Tibetan population and provide theoretical support for the realization of individualized medical treatment for Tibetans in the future.

机译：None

著录项

来源
《Clinical and experimental pharmacology & physiology》 |2021年第5期|共11页
作者
Rong Hao; Dong Hongzhi; He Xue; Yuan Dongya; Bai Mei; Wang Li; Liu Tao; He Yongjun; Zheng Jianwen; Wang Yuhe; Jin Tianbo;
展开▼
作者单位

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

Xizang Minzu Univ Affiliated Hosp Xianyang Peoples R China;

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

Xizang Minzu Univ Affiliated Hosp Xianyang Peoples R China;

Xizang Minzu Univ Affiliated Hosp Xianyang Peoples R China;

Xizang Minzu Univ Sch Med Key Lab Mol Mech &

Intervent Res Plateau Dis Tibe 6 Wenhui Rd;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
dihydropyrimidine dehydrogenase; genetic polymorphism; Tibetan; VIP variants;

机译：二氢嘧啶脱氢酶;遗传多态性;藏族;VIP变体;

相似文献

外文文献
中文文献
专利

1. CAG-repeat variant in the polymerase γ gene and male infertility in the Chinese population： a meta-analysis [J] . Shu-Yuan Liu, Chang-Jun Zhang, Hai-Ying Peng, 亚洲男性学杂志：英文版 . 2011,第002期
2. China’s Tibetan Population and Population in Tibet [J] . 当代中国人口：英文版 . 1996,第002期
3. Variants of Interleukin-7/Interleukin-7 Receptor Alpha are Associated with Both Neuromyelitis Optica and Multiple Sclerosis Among Chinese Han Population in Southeastern China [J] . Jing-Cong Zhuang, Lei Wu, Mei-Zhen Qian, 中华医学杂志（英文版） . 2015,第022期
4. Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China [J] . Xiao-Ling Liu, Hua-Lu Zhao, Guo-Min Shen, Medical science monitor : . 2010,第1期

机译：中国高海拔藏族人群和低海拔汉族人群过氧化物酶体增殖物激活受体γ基因的两个序列变异分析
5. Variants of TLR1 associated with tuberculosis susceptibility in the Chinese Tibetan population but not in Han Chinese [J] . Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases . 2018,第期

机译：TLR1的变异与中国藏人群结核病易感性相关，但在汉族中没有
6. Determinants of self-rated health among an older Tibetan population in a Chinese plateau area: analysis based on the conceptual framework for determinants of health [J] . Yajie Li, Qucuo Nima, Bin Yu, BMC Public Health . 2021,第1期

机译：中国高原地区旧藏人口中自评卫生的决定因素：基于健康决定因素概念框架的分析
7. The Distribution of δ-aminolevulinic Acid Dehydratase Genetic Variants in Uighur and Yi Population of China [C] . Heng Wan The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议）论文集 . 2009

机译：维吾尔族和彝族人群中δ-氨基乙酰丙酸脱水酶遗传变异的分布
8. Analysis of variant alleles of gene thought to affect breast cancer in a patient population from South Carolina. [D] . Occean, Amerline. 2010

机译：对南卡罗来纳州患者人群中可能影响乳腺癌的基因变异等位基因进行分析。
9. Analysis of association between common variants of uncoupling proteins genes and diabetic retinopathy in a Chinese population [O] . Peiyao Jin, Zhiqiang Li, Xian Xu, 2020

机译：中国人群中解偶联蛋白基因常见变异与糖尿病性视网膜病变的相关性分析
10. Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population [O] . Yongchang Guo, Yuju Cao, Shunguo Gong, 2020

机译：中国人口股骨头血管变异与酒精诱导醇骨折的相关分析
11. Global Mineral Resource Assessment: Porphyry Copper Assessment of the Tibetan Plateau, China. [R] . Zientek, M. L., Hammarstrom, J. M., Johnson, K. M., 2012

机译：全球矿产资源评估：中国青藏高原的斑岩铜矿评价。

Analysis of very important pharmacogene variants in the Tibetan population from China

摘要

著录项

相似文献

相关主题

期刊订阅