Allergen skin test reactivity and asthma are inversely associated with ratios of IgG4/IgE and total IgE/allergen-specific IgE in Ugandan communities

Nkurunungi Gyaviira; Nassuuna Jacent; Mpairwe Harriet; Kabagenyi Joyce; Nampijja Margaret; Sanya Richard E.; Webb Emily L.; Elliott Alison M.

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Allergen skin test reactivity and asthma are inversely associated with ratios of IgG4/IgE and total IgE/allergen-specific IgE in Ugandan communities

机译：过敏原皮肤测试反应性和哮喘与乌干达社区中的IgG4 / IgE和总IgE /过敏原特异性IgE的比率相反

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Background Serum inhibition of allergen-specific IgE has been associated with competing IgG4 and non-specific polyclonal IgE. In allergen immunotherapy, beneficial responses have been associated with high IgG4/IgE ratios. Helminths potentiate antibody class switching to IgG4 and stimulate polyclonal IgE synthesis; therefore, we hypothesized a role for helminth-associated IgG4 and total IgE in protection against atopic sensitization and clinical allergy (asthma) in tropical low-income countries.

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来源
《Clinical and experimental allergy :》 |2021年第5期|共13页
作者
Nkurunungi Gyaviira; Nassuuna Jacent; Mpairwe Harriet; Kabagenyi Joyce; Nampijja Margaret; Sanya Richard E.; Webb Emily L.; Elliott Alison M.;
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作者单位

Uganda Virus Res Inst Med Res Council Immunomodulat &

Vaccines Programme POB 49 Plot 51-59;

Uganda Virus Res Inst Med Res Council Immunomodulat &

Vaccines Programme POB 49 Plot 51-59;

Uganda Virus Res Inst Med Res Council Immunomodulat &

Vaccines Programme POB 49 Plot 51-59;

Uganda Virus Res Inst Med Res Council Immunomodulat &

Vaccines Programme POB 49 Plot 51-59;

Uganda Virus Res Inst Med Res Council Immunomodulat &

Vaccines Programme POB 49 Plot 51-59;

Uganda Virus Res Inst Med Res Council Immunomodulat &

Vaccines Programme POB 49 Plot 51-59;

London Sch Hyg &

Trop Med Dept Infect Dis Epidemiol MRC Trop Epidemiol Grp London England;

Uganda Virus Res Inst Med Res Council Immunomodulat &

Vaccines Programme POB 49 Plot 51-59;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
allergen; asthma; IgE; IgG4; Schistosoma; skin prick test;

机译：过敏原;哮喘;IgE;IgG4;血吸虫;皮肤刺测试;

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2. Diagnostic values of combination of free running asthma screening test and total serum allergen IgE level in children with asthma [J] . Chen Xin, Li Yong, Zeng Meiying 中华医学杂志（英文版） . 2014,第005期
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4. Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements [J] . Hamed Aljali, Todd Ian, Tighe Patrick J., Journal of Immunological Methods . 2021,第1期

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10. Allergen skin test reactivity and asthma are inversely associated with ratios of IgG4/IgE and total IgE/allergen‐specific IgE in Ugandan communities [O] . Gyaviira Nkurunungi, Jacent Nassuuna, Harriet Mpairwe, 2021

机译：过敏原皮肤测试反应性和哮喘与乌干达社区的IgG4 / IgE的比率与IgG4 / IgE和总IgE /过敏原特异性IgE的逆转相关
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Allergen skin test reactivity and asthma are inversely associated with ratios of IgG4/IgE and total IgE/allergen-specific IgE in Ugandan communities

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