• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative clinical pathology >Cytoprotective effect of ginger extract on cisplatin-induced hepatorenal toxicity in rats via modulation of oxidative stress, inflammation and apoptosis: histopathological, biochemical and immunohistochemical study
【24h】

Cytoprotective effect of ginger extract on cisplatin-induced hepatorenal toxicity in rats via modulation of oxidative stress, inflammation and apoptosis: histopathological, biochemical and immunohistochemical study

机译：姜提取物对氧化应激，炎症和细胞凋亡的大鼠顺铂诱导的肝肾毒性的细胞保护作用：组织病理学，生物化学和免疫组织化学研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cisplatin (CP) as a potent chemotherapeutic agent is restricted due to its hepatotoxicity, nephrotoxicity, and multiple organ toxicity. The current study investigates the possible mechanisms responsible for the hepatorenal protective effects of ginger extract (GE) against cisplatin-induced hepatorenal toxicity in rats. Thirty-two male albino rats (240-250 g) were divided into four equal groups (n = 8) as follows: control group (single i.p. saline dose 7.5 ml/kg at the 15th day of the study), CP-treated group (7.5 mg/kg single i.p. injection of CP at the 15th day of the study), GE-treated group (500 mg/kg/ p.o daily for 20 days), and GE + CP-treated group (GE 500 mg/kg/day, p.o daily for 15 days prior to CP injection and 5 days after CP injection). At day 21st of the experiment, blood samples were collected, and serum was isolated for biochemical assessments. Then, rats were euthanized, and hepatic and renal tissues were collected for tissue biochemical parameters, histopathology, and immunohistochemistry evaluations. Cisplatin-injected rats showed marked alterations in the serum liver and kidney functions, oxidant/antioxidant biomarkers, pro-inflammatory cytokines; tumor necrosis factor-a (TNF-a), interleukin-1p (IL-1p), and interleukin-6 (IL-6) and anti-inflammatory cytokine; interleukin-10 (IL-10). CP also induced overexpression of oxidative (INOS) and apoptotic (caspase-3) immunohistochemical markers in hepatic and renal tissues. Conversely, the combining administration of ginger extract before, with, and after CP treatment ameliorated the aforementioned biochemical, pathological, and immunohistochemical adverse effects induced by CP. In conclusion, ginger extract has protective effects against CP adverse effects, possibly via its antioxidant, anti-inflammatory, and anti-apoptotic properties.
机译：None

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号