In pursuit of the triple crown: mechanism-based pharmacodynamic modelling for the optimization of three-drug combinations against KPC-producing Klebsiella pneumoniae

Onufrak N. J.; Smith N. M.; Satlin M. J.; Bulitta J. B.; Tan X.; Holden P. N.; Nation R. L.; Li J.; Forrest A.; Tsuji B. T.; Bulman Z. P.

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In pursuit of the triple crown: mechanism-based pharmacodynamic modelling for the optimization of three-drug combinations against KPC-producing Klebsiella pneumoniae

机译：追求三冠：基于机制的药效模型，用于优化针对KPC生产Klebsiella肺炎的三种药物组合

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Objectives: Optimal combination therapy for Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) is unknown. The present study sought to characterize the pharmacodynamics (PD) of polymyxin B (PMB), meropenem (MEM) and rifampin (RIF) alone and in combination using a hollow fibre infection model (HFIM) coupled with mechanism-based modelling (MBM).

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来源
《Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases》 |2020年第9期|共8页
作者
Onufrak N. J.; Smith N. M.; Satlin M. J.; Bulitta J. B.; Tan X.; Holden P. N.; Nation R. L.; Li J.; Forrest A.; Tsuji B. T.; Bulman Z. P.;
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作者单位

Univ N Carolina Dept Pharmacotherapy &

Expt Therapeut Chapel Hill NC 27515 USA;

SUNY Buffalo Dept Pharm Practice Buffalo NY USA;

Weill Cornell Med Dept Med New York NY USA;

Univ Florida Dept Pharmacotherapy &

Translat Res Gainesville FL USA;

Univ Illinois Dept Pharm Practice Chicago IL USA;

SUNY Buffalo Dept Pharm Practice Buffalo NY USA;

Monash Univ Drug Delivery Disposit &

Dynam Melbourne Vic Australia;

Monash Univ Monash Biomed Discovery Inst Melbourne Vic Australia;

Univ N Carolina Dept Pharmacotherapy &

Expt Therapeut Chapel Hill NC 27515 USA;

SUNY Buffalo Dept Pharm Practice Buffalo NY USA;

SUNY Buffalo Dept Pharm Practice Buffalo NY USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Hollow fibre; Mechanism-based model; Pharmacodynamics; Pharmacokinetics; Polymyxin;

机译：中空纤维;基于机制的模型;药效学;药代动力学;polymyxin;

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1. Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice [J] . Xi-Ling Jiang, Hong-Wu Shen, Donald E.Mager, 药学学报：英文版 . 2016,第005期
2. Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice [J] . Xi-Ling Jiang, Hong-Wu Shen, Donald E.Mager, 药学学报（英文版） . 2016,第005期
3. A mechanism-based pharmacokinetic/pharmacodynamic model for CYP3A1/2 induction by dexamethasone in rats [J] . Liang LI, Zai-quan LI, Chen-hui DENG, 中国药理学报：英文版 . 2012,第001期
4. Pharmacodynamics of colistin and fosfomycin: a 'treasure trove' combination combats KPC-producing Klebsiella pneumoniae [J] . Zhao Miao, Bulman Zackery P., Lenhard Justin R., The Journal of Antimicrobial Chemotherapy . 2017,第7期

机译：山药和福斯霉素的药效学：“宝库”组合作战核科昆明肺炎肺炎
5. Modeling Meropenem Treatment, Alone and in Combination with Daptomycin, for KPC-Producing Klebsiella pneumoniae Strains with Unusually Low Carbapenem MICs [J] . Gagetti P., Pasteran F., Martinez M. P., Antimicrobial agents and chemotherapy. . 2016,第8期

机译：单独和与达托霉素组合使用美罗培南治疗的模型，用于产生KPC的肺炎克雷伯菌，异常低碳青霉烯MIC
6. Modeling Meropenem Treatment, Alone and in Combination with Daptomycin, for KPC-Producing Klebsiella pneumoniae Strains with Unusually Low Carbapenem MICs [J] . Gagetti P., Pasteran F., Martinez M. P., Antimicrobial agents and chemotherapy. . 2016,第8期

机译：将单独和与达达霉素组合建模的梅洛宁治疗，为KPC生产的Klebsiella肺炎群菌株具有异常低的Carbapenem MICS
7. Optimization of expression conditions of dhaT gene from Klebsiella pneumoniae in Escherichia coli using uniform design [C] . China-Japan-Korea Joint Symposium on Enzyme Engineering . 2004

机译：均匀设计法优化肺炎克雷伯菌dhaT基因在大肠杆菌中的表达条件。
8. Optimizing polymyxin antibiotics using combination therapy and mechanism-based models [D] . Ly, Neang S. 2014

机译：结合疗法和基于机制的模型优化多粘菌素抗生素
9. Pharmacodynamics of colistin and fosfomycin: a ‘treasure trove’ combination combats KPC-producing Klebsiella pneumoniae [O] . Miao Zhao, Zackery P. Bulman, Justin R. Lenhard, -1

机译：大肠菌素和磷霉素的药效学：宝藏组合可对抗生产KPC的肺炎克雷伯菌
10. Pharmacodynamics of colistin and fosfomycin: a ‘treasure trove’ combination combats KPC-producing Klebsiella pneumoniae [O] . Miao Zhao, Zackery P. Bulman, Justin R. Lenhard, 2017

机译：Colistin和Fosfomycin的药效学：一个“宝库”组合作战KPC生产Klebsiella肺炎
11. Dermal Wound Transcriptomic Responses to Infection with Pseudomonas aeruginosa versus Klebsiella pneumoniae in a Rabbit Ear Wound Model. [R] . Leung, K. P., D'Arpa, P., Seth, A. K., 2014

机译：兔耳损伤模型中铜绿假单胞菌与肺炎克雷伯菌感染的皮肤创伤转录组学反应。

In pursuit of the triple crown: mechanism-based pharmacodynamic modelling for the optimization of three-drug combinations against KPC-producing Klebsiella pneumoniae

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