Low-grade Serous Tumors: Are We Making Progress?

Pauly Nina; Ehmann Sarah; Ricciardi Enzo; Ataseven Beyhan; Bommert Mareike; Heitz Florian; Prader Sonia; Schneider Stephanie; du Bois Andreas; Harter Philipp; Baert Thais

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Low-grade Serous Tumors: Are We Making Progress?

机译：低级浆液肿瘤：我们正在取得进展吗？

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Purpose of Review This review provides an overview of the current clinical standard in low-grade serous ovarian cancer (LGSOC). The available evidence for surgery and standard treatments is elaborated. In addition, we discuss recent findings and novel treatments for LGSOC. Recent Findings Two large multicenter trials studying MEK inhibitors in LGSOC have been presented in the last year. Binimetinib demonstrated an activity in LGSOC, especially in KRAS-mutated disease. Trametinib was associated with an improved progression-free survival in relapsed LGSOC. Based on the current results, MEK inhibitors could be an alternative treatment for LGSOC. Surgery is an important step in the treatment of LGSOC. Hormonal therapy and bevacizumab can be beneficial, next to chemotherapy. Targeted treatments, such as the MEK-inhibitor trametinib, seem to be efficient and should be introduced into clinical practice.

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来源
《Current oncology reports.》 |2020年第6期|共6页
作者
Pauly Nina; Ehmann Sarah; Ricciardi Enzo; Ataseven Beyhan; Bommert Mareike; Heitz Florian; Prader Sonia; Schneider Stephanie; du Bois Andreas; Harter Philipp; Baert Thais;
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作者单位

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

Kliniken Essen Mitte Gynaecol &

Gynaecol Oncol Henricistr 92 D-45136 Essen Germany;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Ovarian cancer; Low-grade serous; rare tumor; MEK inhibitor;

机译：卵巢癌;低级浆液;罕见肿瘤;MEK抑制剂;

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专利

1. Case Report ex VivoOocyte Collection to Maintain Fertility in a Patient with Micropapillary Serous Borderline Ovarian Tumor [J] . Jitka Rezacova, Petr Safar, Lucie Petrouskova, 生殖科学（英文） . 2021,第002期
2. Intratumoral Heterogeneity Accounts for Apparent Progression of Noninvasive Serous Tumors to Invasive Low-grade Serous Carcinoma: A Study of 30 Low-grade Serous Tumors of the Ovary in 18 Patients With Peritoneal Carcinomatosis [J] . Seidman Jeffrey D., Savage Johanna, Krishnan Jayashree, International journal of gynecological pathology: Official journal of the International Society of Gynecological Pathologists . 2020,第1期

机译：肿瘤内血液血液癌的非侵入性浆液肿瘤的明显进展的肿瘤内异质性：18例腹膜癌症患者的30例低级血液肿瘤的研究
3. Low-grade ovarian serous neoplasms (low-grade serous carcinoma and serous borderline tumor) associated with high-grade serous carcinoma or undifferentiated carcinoma: Report of a series of cases of an unusual phenomenon [J] . BoydC., McCluggageW.G. American Journal of Surgical Pathology . 2012,第3期

机译：与高级别浆液性癌或未分化癌相关的低度卵巢浆液性肿瘤（低度浆液性癌和浆液性交界性肿瘤）：一系列异常现象的报告
4. Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma [J] . Stewart L. M., Stewart C. J. R., Spilsbury K., Gynecologic Oncology: An International Journal . 2020,第3期

机译：盆腔炎疾病，不孕症，异位妊娠与卵巢浆液边缘肿瘤，粘液边缘肿瘤和低级浆液癌之间的关联
5. Classification of serous ovarian tumors based on microarray data using multicategory support vector machines [C] . Park Jee Soo, Beom Choi Soo, Chung Jai Won, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：使用多类别支持向量机基于微阵列数据对浆液性卵巢肿瘤进行分类
6. Data mining the serous ovarian tumor transcriptome [D] . Tickle, Timothy Lee 2011

机译：浆液性卵巢肿瘤转录组的数据挖掘
7. CT Features of Ovarian Tumors: Defining Key Differences Between Serous Borderline Tumors and Low-Grade Serous Carcinomas [O] . Stephanie Nougaret, Yulia Lakhman, Nicolas Molinari, -1

机译：卵巢肿瘤的CT特征：浆液性交界性肿瘤与低度浆液性癌的关键区别
8. Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma [O] . L.M. Stewart, C.J.R. Stewart, K. Spilsbury, 2020

机译：盆腔炎症疾病，不孕，异位妊娠与卵巢浆液围绕肿瘤，粘液边缘肿瘤和低级浆液癌的关系
9. Pathogenesis of Ovarian Serous Carcinoma as the Basis for Immunologic Directed Diagnosis and Treatment. Project 1 - Molecular Characterization of Ovarian Serous Tumors Developing Along Different Pathways [R] . Kurman, R. J. , Shih, I. 2003

机译：卵巢浆液性癌的发病机制是免疫定向诊断和治疗的基础。项目1 - 沿不同途径发展的卵巢浆液性肿瘤的分子特征

Low-grade Serous Tumors: Are We Making Progress?

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