The Emerging Role of Local Therapy in Metastatic Prostate Cancer

Sundahl Nora; Tree Alison; Parker Chris

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The Emerging Role of Local Therapy in Metastatic Prostate Cancer

机译：局部治疗在转移性前列腺癌中的新兴作用

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Purpose of Review This review summarizes the prospective clinical evidence regarding local therapy in metastatic prostate cancer. Recent Findings The phase 3 STAMPEDE trial showed that prostate radiotherapy confers a survival benefit for newly diagnosed patients with low volume metastatic hormone-sensitive prostate cancer (HSPC). No survival benefit was noted for those with high volume disease. A subsequent meta-analysis combining the data of the STAMPEDE trial with that of the HORRAD trial corroborated these findings. The phase 2 randomized STOMP trial investigated local treatment of metastases in patients with oligometastatic HSPC, and showed an improvement in hormone therapy-free survival. Local prostate radiotherapy should be offered to patients with newly diagnosed low volume metastatic HSPC. Early clinical evidence suggests that local treatment to metastatic disease might be beneficial for patients with oligometastatic HSPC, but larger trials are awaited.

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《Current oncology reports.》 |2020年第6期|共6页
作者
Sundahl Nora; Tree Alison; Parker Chris;
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作者单位

Royal Marsden Hosp Urol Oncol Dept Downs Rd London SM2 5PT England;

Royal Marsden Hosp Urol Oncol Dept Downs Rd London SM2 5PT England;

Royal Marsden Hosp Urol Oncol Dept Downs Rd London SM2 5PT England;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Prostate cancer; Radiotherapy; Hormone-sensitive prostate cancer; Hormone therapy-relapsed prostate cancer;

机译：前列腺癌;放疗;激素敏感前列腺癌;激素治疗 - 复发前列腺癌;

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1. The emerging role of prostate-specific membrane antigen(PSMA)PET-CT in patients with high-risk prostate cancer:moving the bar in high-risk prostate cancer [J] . Jeanny B Aragon-Ching 亚洲男性学杂志（英文版） . 2021,第001期
2. Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy [J] . Jeremy YC Teoh, James HL Tsu, Steffi KK Yuen, 亚洲男性学杂志（英文版） . 2017,第001期
3. Human epidermal growth factor receptor type 2 protein expression in Chinese metastatic prostate cancer patients correlates with cancer specific survival and increases after exposure to hormonal therapy [J] . Bo Dai, Yun-Yi Kong, Ding-Wei Ye, 亚洲男性学杂志（英文版） . 2008,第005期
4. Prostate cancer: The role of local therapy for metastatic prostate cancer. [J] . Lorenzo Tosco, Hendrik Van Poppel Nature reviews. Urology . 2014,第3期

机译：前列腺癌：转移性前列腺癌的局部治疗作用。
5. Emerging Role for Local Therapy in Oligometastatic Prostate Cancer [J] . Nabila R. Khondakar, Jeunice Owens-Walton, Michael Daneshvar, Clinical advances in hematology & oncology: H&O . 2021,第7期

机译：局部疗法在寡粒子瘤前列腺癌中的新兴作用
6. Re: A systematic review of contemporary management of oligometastatic prostate cancer: fighting a challenge or tilting at windmills? From Slaoui et al., World J urol 2019. Long-term safety of local radiation therapy of newly diagnosed low burden metastatic prostate cancer: an unaddressed concern [J] . World journal of urology . 2019,第11期

机译：RE：对寡粒子瘤前列腺癌的当代管理的系统审查：在风车上争取挑战或倾斜？来自Slaoui等人。，世界J Urol 2019.新诊断的低负担转移前列腺癌的局部放射治疗的长期安全性：一个禁止的关注
7. Identification of Circulating Pluripotent Cancer Stem Cells in the Blood of Prostate Cancer Patients for the Diagnosis of Metastatic Cancer [C] . Anette Claudia Schafer, Yawen Ju, Youngbin Tak, International Molecular Medicine Tri-Conference. . 2016

机译：鉴定前列腺癌患者血液中循环多能癌症干细胞诊断转移性癌症
8. Muscle Cross-Sectional Area Is Improved and Physical Funciton Is Maintained After Home-Based Exercise in Men with Metastatic Castration-Resistant Prostate Cancer Undergoing Androgen Deprivation Therapy [D] . Alzer, Mohamdod Saber. 2020

机译：改善肌横截面积，并且在具有转移阉割的前列腺癌接受雄激素剥夺治疗的男性中的男性锻炼之后，将物理静脉凝集维持
9. Radical Prostatectomy or External Beam Radiation Therapy versus No Local Therapy for Survival Benefit in Metastatic Prostate Cancer - A SEER-Medicare Analysis [O] . Raj Satkunasivam, Andre E. Kim, Mihir Desai, -1

机译：前列腺癌根治术或外部放射治疗与无局部治疗对转移性前列腺癌的生存获益-SEER-Medicare分析
10. Additional Local Therapy for Liver Metastases in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Systemic PSMA-Targeted Therapy [O] . Robert Seifert, Katharina Kessel, Martin Boegemann, 2019

机译：患者转移阉割抗性前列腺癌患者肝转移的额外局部疗法，接受全身性PSMA靶向治疗
11. Prostate Specific Membrane Antigen (PSMA) Targeted Bio-orthogonal Therapy for Metastatic Prostate Cancer. [R] . Artemov, D. 2017

机译：前列腺特异性膜抗原（psma）靶向生物正交治疗转移性前列腺癌。

The Emerging Role of Local Therapy in Metastatic Prostate Cancer

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