Therapy of Peripheral T Cell Lymphoma: Focus on Nodal Subtypes

Allen Pamela B.; Pro Barbara

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Therapy of Peripheral T Cell Lymphoma: Focus on Nodal Subtypes

机译：外周T细胞淋巴瘤的治疗：专注于节点亚型

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Purpose of ReviewPeripheral T cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas with inferior prognosis compared with their B cell counterparts characterized by frequent relapses, resulting in a median 5-year survival of approximately 30%. Their diverse clinicopathologic features challenge existing treatment paradigms that treat all patients uniformly. Here we review recent advances in the treatment of these diseases.Recent FindingsWhile current treatment still relies largely on combination chemotherapy, the introduction of more effective novel and targeted therapies has improved outcomes in certain subtypes. Increasing understanding of the underlying biology of PTCL has prompted further subclassification by genetic and molecular subgroups.SummaryOverall, the most significant advances in PTCL management have resulted from improved understanding and classification of the biology of PTCL. Ongoing development of subtype-specific targeted therapies will be essential to improve long-term outcomes of patients with these diseases.

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来源
《Current oncology reports.》 |2020年第6期|共10页
作者
Allen Pamela B.; Pro Barbara;
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作者单位

Emory Univ Winship Inst 1365 Clifton Rd NE Suite 4400 Atlanta GA 30322 USA;

Northwestern Univ Robert H Lurie Comprehens Canc Ctr Feinberg Sch Med Dept Med Div Hematol Oncol;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Peripheral T cell lymphoma; Angioimmunoblastic T cell lymphoma; Anaplastic large-cell lymphoma; Therapy; Relapsed disease;

机译：外周T细胞淋巴瘤;血管免疫细胞淋巴瘤;促进的大细胞淋巴瘤;治疗;复发疾病;

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Therapy of Peripheral T Cell Lymphoma: Focus on Nodal Subtypes

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