Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

Timothy M Hall; Marie-Pier Tétreault; Kathryn E Hamilton; Kelly A Whelan

首页> 外文期刊>Current opinion in pharmacology >Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

【24h】

Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

机译：食管鳞状细胞癌中的自噬作自噬是食管鳞状细胞癌的细胞保护机制

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.

机译：None

著录项

来源
《Current opinion in pharmacology》 |2018年第2018期|共8页
作者
Timothy M Hall; Marie-Pier Tétreault; Kathryn E Hamilton; Kelly A Whelan;
展开▼
作者单位

Lewis Katz School of Medicine at Temple University;

Department of Medicine Gastroenterology and Hepatology Division Northwestern University Feinberg;

Department of Pediatrics Division of Gastroenterology Hepatology and Nutrition Children's;

Department of Pathology &

Laboratory Medicine Lewis Katz School of Medicine at Temple University;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词

相似文献

外文文献
中文文献
专利

1. Insulin enhances apoptosis induced by cisplatin in human esophageal squamous cell carcinoma EC9706 cells related to inhibition of autophagy [J] . Yang Yang, Wen Fengbiao, Dang Lifeng, 中华医学杂志（英文版） . 2014,第002期
2. Nuclear Factor-κB Signaling Pathway Constitutively Activated in Esophageal Squamous Cell Carcinoma Cell Lines and Inhibition of Growth of Cells by Small Interfering RNA [J] . Fang TIAN, Wei-Dong ZANG, Wei-Hong HOU, 生物化学与生物物理学报：英文版 . 2006,第005期
3. Signatures within esophageal microbiota with progression of esophageal squamous cell carcinoma [J] . Minjuan Li, Dantong Shao, Jiachen Zhou, 中国癌症研究（英文版） . 2020,第006期
4. Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma [J] . Timothy M Hall, Marie-Pier Tétreault, Kathryn E Hamilton, Current opinion in pharmacology . 2018,第期

机译：食管鳞状细胞癌中的自噬作自噬是食管鳞状细胞癌的细胞保护机制
5. Autophagy: A Potential Mechanism for Resistance of Esophageal Squamous Cell Carcinoma to Therapy [J] . Dong-Lei Liu, Ji-Guang Zhang, Jian-Jun Wang Journal of the Formosan Medical Association =: Taiwan yi zhi . 2010,第11期

机译：自噬：食管鳞状细胞癌治疗的潜在机制
6. BNIP3 induces apoptosis and protective autophagy under hypoxia in esophageal squamous cell carcinoma cell lines: BNIP3 regulates cell death [J] . Ma Z., Chen C., Tang P., Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus . 2017,第9期

机译：BNIP3在食管鳞状细胞癌细胞系中诱导缺氧下的细胞凋亡和保护性自噬：BNIP3调节细胞死亡
7. An Actin-Binding Protein ESPN Is an Independent Prognosticator and Regulates Cell Growth for Esophageal Squamous Cell Carcinoma [C] . Hsin-Ting Tsai International Molecular Medicine Tri-Conference. . 2019

机译：肌动蛋白结合蛋白ESPN是一个独立的预测者，并调节食管鳞状细胞癌的细胞生长
8. Identification of Novel Candidate Tumor Suppressor Genes at 11q and 15q for Esophageal Squamous Cell Carcinoma and Nasopharyngeal Carcinoma via Integrative Cancer Epigenetics and Genomics. [D] . Li, Jisheng. 2010

机译：通过综合癌症表观遗传学和基因组学鉴定食管鳞状细胞癌和鼻咽癌的11q和15q新型候选肿瘤抑制基因。
9. Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma [O] . Timothy M. Hall, Marie-Pier Tétreault, Kathryn E. Hamilton, -1

机译：自噬作为食管鳞状细胞癌的细胞保护机制
10. Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma [O] . Timothy M Hall, Marie-Pier Tétreault, Kathryn E Hamilton, 2018

机译：食管鳞状细胞癌中的自噬作自噬作用
11. Lung Squamous Cell Carcinoma Stem Cells as Immunotherapy Targets. [R] . Kim, C. 2017

机译：肺鳞状细胞癌干细胞作为免疫治疗靶点。

Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

摘要

著录项

相似文献

相关主题

期刊订阅