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首页> 外文期刊>Abdominal radiology. >The combination of Child-Pugh score and quantitative CT-based spleen volume could predict the risk of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt creation
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The combination of Child-Pugh score and quantitative CT-based spleen volume could predict the risk of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt creation

机译：Child-Pugh得分和定量CT的脾脏体积的组合可以预测秘方静脉内部PortoSystemics Spruntion后肝脑病的风险

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摘要

Purpose Hepatic encephalopathy (HE) is a common complication in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS). The objective of this study was to assess the prognostic factors and make risk stratification of post-TIPS HE. Methods This was a retrospective cohort study consisting of cirrhotic patients who had undergone TIPS creation at our center from November 2015 to August 2020. The baseline characteristics including spleen volume (SVol) and other markers were collected. The univariate and multivariate Cox regression analyses were used to identify independent predictors of post-TIPS overt HE (OHE). Results Higher Child-Pugh (CP) score (HR 1.334, 95% CI 1.090-1.632, P = 0.005) and smaller SVol (HR 0.999, 95% CI 0.997-1.000, P = 0.004) were identified as the independent risk factors for post-TIPS OHE. And a time-dependent ROC analysis was used to determine the cutoff values of CP score and SVol, which were respectively 6.5 and 773 cm(3). Subsequently, the CP-SVol grading system was developed to divide patients into three risk grades according to the above two cutoff values. Kaplan-Meier analysis showed that the cumulative rates of patients free of OHE in Grade 1, 2 and 3 were respectively 96.4% +/- 3.5%, 82.1 +/- 4.7%, and 59.3% +/- 6.4%, which were in descending order (Log rank P < 0.001). Conclusion SVol might be a novel marker to predict the prognosis of post-TIPS OHE, and the proposed CP-SVol grading system composed of CP score and SVol achieved a superior predictive performance.
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  • 来源
    《Abdominal radiology.》 |2021年第7期|共7页
  • 作者

    Liu Jiacheng; Zhou Chen; Wang Yingliang; Yang Chongtu; Shi Qin; Huang Songjiang; Chen Yang; Li Tongqiang; Xiong Bin;

  • 作者单位

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

    Huazhong Univ Sci &

    Technol Dept Radiol Union Hosp Tongji Med Coll Jiefang Ave 1277 Wuhan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内科学;
  • 关键词

    Transjugular intrahepatic portosystemic shunt; Hepatic encephalopathy; Spleen volume; Childamp; 8211; Pugh score; Prognostic factors;

    机译：Transjugulular肝内portoSystemic分流器;肝脑病;脾脏卷;儿童＆amp;8211;pugh得分;预后因素;

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