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首页> 外文期刊>Acta biomaterialia >Prolonged, acute suppression of cysteinyl leukotriene to reduce capsular contracture around silicone implants
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Prolonged, acute suppression of cysteinyl leukotriene to reduce capsular contracture around silicone implants

机译：长时间，急性抑制膀胱丁基白酮，以减少硅氧烷植入物周围的囊状挛缩

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摘要

Graphical abstract Display Omitted Abstract We hypothesize that periodically early, local suppression of cysteinyl leukotrienes (CysLTs), which are potent inflammatory mediators, can reduce the fibrotic capsular contracture around silicone implants. We tested this hypothesis with the silicone implants enabled with the sustained release of montelukast, a CysLT receptor antagonist, for 3 and 15 days. In this work, we inserted each of the distinct implants into the pocket of the subpanniculus carnosus plane of living rats and performed histological and immunofluorescent (IF) analyses of the tissues biopsied at predetermined periods for 12 weeks after implant insertion. The implants with montelukast exhibited significantly reduced polymorphonuclear leukocytes (i.e., PMNs), implying a concurrent reduction of CysLT. This effect was more prominent after long-term local montelukast exposure. Thus, fewer fibroblasts were recruited, thereby reducing transforming growth factor (TGF)-β and myofibroblasts in the tissue around the implant. Therefore, the fibrotic capsule formation, which was assessed using the capsule thickness and collagen density, decreased along with the myofibroblasts. Additionally, the tissue biopsied at the experimental end point exhibited significantly decreased mechanical stiffness. Statement of Significance Capsular contracture is troublesome, making the tissues hardened around the silicone implant. This causes serious pain and discomfort to the patients, often leading to secondary surgery for implant replacement. To resolve this, we suggest a strategy of long-term, local suppression of cysteinyl leukotriene, an important mediator present during inflammation. For this, we propose a silicone implant abled to release a drug, montelukast, in a sustained manner. We tested our drug-release implant in living animals, which exhibited a significant decrease in capsule formation compared with the intact silicone implant. Therefore, we conclude that the sustained release of montelukast at the local insertion site represents a promising way to reduce capsular contracture around silicone implants.
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  • 来源
    《Acta biomaterialia》 |2017年第1期|共11页
  • 作者

    Byung Hwi Kim; Min Park; Hyo Jin Park; Seung Ho Lee; Sung Yoon Choi; Chun Gwon Park; Su Min Han; Chan Yeong Heo; Young Bin Choy;

  • 作者单位

    Department of Biomedical Engineering College of Medicine Seoul National University;

    Interdisciplinary Program in Bioengineering College of Engineering Seoul National University;

    Department of Pathology Seoul National University Bundang Hospital;

    Institute of Medical &

    Biological Engineering Medical Research Center Seoul National University;

    Interdisciplinary Program in Bioengineering College of Engineering Seoul National University;

    Institute of Medical &

    Biological Engineering Medical Research Center Seoul National University;

    Department of Biomedical Engineering College of Medicine Seoul National University;

    Department of Plastic and Reconstructive Surgery College of Medicine Seoul National University;

    Department of Biomedical Engineering College of Medicine Seoul National University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Cysteinyl leukotrienes; Fibrosis; Fibroblast; Montelukast; Myofibroblasts; Silicone implants; TGF-β;

    机译：纤维化;纤维化;成纤维细胞;montelukast;myofbroblasts;硅胶植入物;TGF-β;

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