Synthesis, structure and in vitro cytotoxicity testing of some 2-aroylbenzofuran-3-ols

Nguyen Tien Cong; Huynh Thi Xuan Trang; Pham Duc Dung; Tran Hoang Phuong; Vu Quoc Trung; Nguyen Dang Dat; Dang Thi Tuyet Anh; Nguyen Van Tuyen; Luc Van Meervelt

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Synthesis, structure and in vitro cytotoxicity testing of some 2-aroylbenzofuran-3-ols

机译：一些2-aroylbenzofuran-3-Ols的合成，结构和体外细胞毒性试验

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Five 2-aroyl-5-bromobenzo[b]furan-3-ol compounds (two of which are new) and four new 2-aroyl-5-iodobenzo[b]furan-3-ol compounds were synthesized starting from salicylic acid. The compounds were characterized by mass spectrometry and H-1 NMR and C-13 NMR spectroscopy. Single-crystal X-ray diffraction studies of four compounds, namely, (5-bromo-3-hydroxybenzofuran2-yl)(4-fluorophenyl)methanone, C15H8BrFO3, (5-bromo-3-hydroxybenzofuran2-yl)(4-chlorophenyl)methanone, C15H8BrClO3, (5-bromo-3-hydroxybenzofuran2-yl)(4-bromophenyl)methanone, C15H8Br2O3, and (4-bromophenyl)(3-hydroxy5-iodobenzofuran-2-yl)methanone, C15H8BrIO3, were also carried out. The compounds were tested for their in vitro cytotoxicity on the four human cancer cell lines KB, Hep-G2, Lu-1 and MCF7. Six compounds show good inhibiting abilities on Hep-G2 cells, with IC50 values of 1.39-8.03 mu M.

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来源
《Acta crystallographica. Section C, Structural chemistry.》 |2020年第9期|共28页
作者
Nguyen Tien Cong; Huynh Thi Xuan Trang; Pham Duc Dung; Tran Hoang Phuong; Vu Quoc Trung; Nguyen Dang Dat; Dang Thi Tuyet Anh; Nguyen Van Tuyen; Luc Van Meervelt;
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作者单位

Ho Chi Minh City Univ Educ Fac Chem 280 An Duong Vuong St Dist 5 Ho Chi Minh City Vietnam;

Ho Chi Minh City Univ Educ Fac Chem 280 An Duong Vuong St Dist 5 Ho Chi Minh City Vietnam;

Ho Chi Minh City Univ Educ Fac Chem 280 An Duong Vuong St Dist 5 Ho Chi Minh City Vietnam;

Vietnam Natl Univ Univ Sci Fac Chem 227 Nguyen Van Cu St Dist 5 Ho Chi Minh City 721337 Vietnam;

Hanoi Natl Univ Educ Fac Chem 136 Xuan Thuy Hanoi 100000 Vietnam;

Hanoi Natl Univ Educ Fac Chem 136 Xuan Thuy Hanoi 100000 Vietnam;

Viet Nam Acad Sci &

Technol Inst Chem 18 Hoang Quoc Viet Hanoi 100000 Vietnam;

Viet Nam Acad Sci &

Technol Inst Chem 18 Hoang Quoc Viet Hanoi 100000 Vietnam;

Katholieke Univ Leuven Dept Chem Celestijnenlaan 200F POB 2404 B-3001 Heverlee Belgium;

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原文格式 PDF
正文语种 eng
中图分类晶体学;
关键词
2-aroylbenzofuran-3-ol; bromo-salicylate; iodosalicylate; crystal structure; cytotoxicity;

机译：2-aroylbenzofuran-3-ol;溴 - 水杨酸盐;碘化物;晶体结构;细胞毒性;

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Synthesis, structure and in vitro cytotoxicity testing of some 2-aroylbenzofuran-3-ols

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