SOCS1 in cancer: An oncogene and a tumor suppressor

Beaurivage Claudia; Champagne Audrey; Tobelaim William S.; Pomerleau Veronique; Menendez Alfredo; Saucier Caroline

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SOCS1 in cancer: An oncogene and a tumor suppressor

机译：癌症中的SOCS1：癌基因和肿瘤抑制剂

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The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.

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来源
《Cytokine》 |2016年第1期|共8页
作者
Beaurivage Claudia; Champagne Audrey; Tobelaim William S.; Pomerleau Veronique; Menendez Alfredo; Saucier Caroline;
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作者单位

Univ Sherbrooke Fac Med &

Hlth Sci Dept Anat &

Cell Biol Sherbrooke PQ J1K 2R1 Canada;

Univ Sherbrooke Fac Med &

Hlth Sci Dept Anat &

Cell Biol Sherbrooke PQ J1K 2R1 Canada;

Univ Sherbrooke Fac Med &

Hlth Sci Dept Anat &

Cell Biol Sherbrooke PQ J1K 2R1 Canada;

Univ Sherbrooke Fac Med &

Hlth Sci Dept Anat &

Cell Biol Sherbrooke PQ J1K 2R1 Canada;

Univ Sherbrooke Fac Med &

Hlth Sci Dept Microbiol &

Infect Dis Sherbrooke PQ J1K 2R1 Canada;

Univ Sherbrooke Fac Med &

Hlth Sci Dept Anat &

Cell Biol Sherbrooke PQ J1K 2R1 Canada;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
SOCS1; Cytokine; Cancer; Tumor suppressor; Oncogene; Colorectal cancer;

机译：SOCS1;细胞因子;癌症;肿瘤抑制剂;癌症;结直肠癌;

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1. Effect of cisplatin-based concurrent radiochemotherapy on malignant degree of advanced cervical cancer and expression of proto-oncogene and tumor suppressor genes [J] . 海南医科大学学报（英文版） . 2017,第014期
2. Relationship of ultrasonic shear wave velocity with oncogene and tumor suppressor gene expression in primary liver cancer lesions as well as angiogenesis factor contents [J] . Xing Yin, Hua He, Zi-Chang Niu 海南医科大学学报（英文版） . 2017,第012期
3. Effect of cisplatin-based concurrent radiochemotherapy on malignant degree of advanced cervical cancer and expression of proto-oncogene and tumor suppressor genes [J] . Rui-Juan Jia, Yang Zhang, Ju-Lang Dong, 海南医科大学学报(英文版) . 2017,第014期
4. Relationship of ultrasonic shear wave velocity with oncogene and tumor suppressor gene expression in primary liver cancer lesions as well as angiogenesis factor contents [J] . Xing Yin, Hua He, Zi-Chang Niu 海南医科大学学报(英文版) . 2017,第012期
5. DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors. [J] . Hussain S, Zhang Y, Galardy PJ Cell cycle . 2009,第11期

机译：DUB和癌症：去泛素化酶作为癌基因，非癌基因和抑癌剂的作用。
6. MiR-29a inhibits invasion and metastasis of cervical cancer via modulating methylation of tumor suppressor SOCS1 [J] . Gong Yi, Wan Jun-Hui, Zou Wei, Future oncology . 2019,第15期

机译：MiR-29A通过调节肿瘤抑制作用SOCS1的甲基化抑制宫颈癌的侵袭和转移
7. Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer [J] . Martin Chevrier, Diwakar Bobbala, Alberto Villalobos-Hernandez, BMC Cancer . 2017,第1期

机译：SOCS1及其可能的抑癌功能下游靶标在前列腺癌中的表达
8. Oncogenes and tumor suppressor genes in murine tumors induced by neutron- or gamma-irradiation in utero [C] . Sara Antal, K. Lumniczky, J. Palfalvi, International Symposium of Radiation and Homeostasis . 2002

机译：子宫中子或γ-辐照诱导的鼠肿瘤中的癌肠和肿瘤抑制基因
9. Oncogene-mediated Inhibition of the Spred1 Tumor Suppressor [D] . Markegard, Evan Curtis. 2018

机译：癌基因介导的Spred1肿瘤抑制因子的抑制作用
10. Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer [O] . Martin Chevrier, Diwakar Bobbala, Alberto Villalobos-Hernandez, 2017

机译：SOCS1及其可能的抑癌功能下游靶标在前列腺癌中的表达
11. Evaluación del estado de metilación de genes supresores tumorales y amplificación de oncogenes, como marcadores moleculares en DNA libre en plasma de pacientes con cáncer pulmonar, atendidos en cuatro hospitales de Bogotá – Colombia / Evaluation of methylation status of tumor suppressor genes and amplification of oncogenes, as molecular markers in free DNA in plasma of patients with lung cancer, treated in four hospitals in Bogotá – Colombia. [O] . Álvarez Mogollón Alba Mayerly 2011

机译：评估肿瘤抑制基因的甲基化状态和扩增癌基因，如肺癌患者无血浆DNa中的分子标记，在波哥大的四家医院进行治疗 - 哥伦比亚/评估肿瘤抑制基因的甲基化状态和扩增癌基因，作为肺癌患者血浆游离DNa的分子标志物，在波哥大 - 哥伦比亚的四家医院接受治疗。
12. Differential Splicing of Oncogenes and Tumor Suppressor Genes in African- and Caucasian-American Populations: Contributing Factor in Prostate Cancer Disparities. [R] . Lee, N. H., Wang, B., Olender, J. 2016

机译：非洲裔和高加索裔美国人群中致癌基因和肿瘤抑制基因的差异剪接：前列腺癌差异的促成因素。

SOCS1 in cancer: An oncogene and a tumor suppressor

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