Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3

Murphy Philip M.; Heusinkveld Lauren

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Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3

机译：CXCL12及其受体CXCR4和ACKR3的多系统多任务处理

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Chemokines are named and best known for their chemotactic cytokine activity in the hematopoietic system; however, their importance extends far beyond leukocytes, cell movement and immunoregulation. CXCL12, the most protean of chemokines, regulates development in multiple systems, including the hematopoietic, cardiovascular and nervous systems, and regulates diverse cell functions, including differentiation, distribution, activation, immune synapse formation, effector function, proliferation and survival in the immune system alone. The broad importance of CXCL12 is revealed by the complex lethal developmental phenotypes in mice lacking either Cxcl12 or either one of its two known 7-transmembrane domain receptors Cxcr4 and Ackr3, as well as by gain-of function mutations in human CXCR4, which cause WHIM syndrome, a multisystem and combined immunodeficiency disease and the only Mendelian condition caused by a chemokine system mutation. In addition, wild type CXCR4 is important in the pathogenesis of HIV/AIDS and cancer. Thus, CXCL12 and its receptors CXCR4 and ACKR3 provide extraordinary examples of multisystem multitasking in the chemokine system in both health and disease.

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来源
《Cytokine》 |2018年第2018期|共9页
作者
Murphy Philip M.; Heusinkveld Lauren;
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作者单位

NIAID Lab Mol Immunol NIH 9000 Rockville Pike Bethesda MD 20892 USA;

NIAID Lab Mol Immunol NIH 9000 Rockville Pike Bethesda MD 20892 USA;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Chemokine; WHIM syndrome; HIV; Development; Hematopoiesis; Leukocyte;

机译：趋化因子;致命综合征;艾滋病毒;发展;血小霉素;白细胞;

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2. New G-protein-coupled receptor structures provide insights into the recognition of CXCL12 and HIV-1 gp120 by CXCR4 [J] . Chen Zhong, Jianping Ding 生物化学与生物物理学报：英文版 . 2011,第005期
3. New G-protein-coupled receptor structures provide insights into the recognition of CXCL12 and HIV-1 gp120 by CXCR4 [J] . Chen Zhong, Jianping Ding 生物化学与生物物理学报：英文版 . 2011,第005期
4. Roles of Chemokine Receptor 4 （CXCR4） and Chemokine Ligand 12 （CXCL12） in Metastasis of Hepatocellular Carcinoma Cells [J] . Hui Liu, Zeya Pan, Aijun Li, 细胞与分子免疫学：英文版 . 2008,第005期
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6. Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3 [J] . Murphy Philip M., Heusinkveld Lauren Cytokine . 2018,第期

机译：CXCL12及其受体CXCR4和ACKR3的多系统多任务处理
7. Differential activity and selectivity of N‐terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors [J] . Agnieszka JaraczRos, Guillaume Bernadat, Pasquale Cutolo, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2020,第6期

机译：N-末端改性CXCL12趋化因子在CXCR4和ACKR3受体中的差异活性和选择性
8. Differential activity and selectivity of N‐terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors [J] . Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2020,第6期

机译：N-末端改性CXCL12趋化因子在CXCR4和Ackr3受体中的差异活性和选择性
9. Predicting the Co-receptors (CCR5 and CXCR4) of the Viruses R5, X4 and R5X4 that Cause AIDS (HIV-1) in Cells CD4 using The Bayes Classifier [C] . Francisco Javier Luna Rosas, Julio Cesar Martinez Romo, Carlos Alejandro de Luna Ortega, International Conference on Bioinformatics and Computational Biology . 2014

机译：预测病毒R5，X4和R5X4的共同受体（CCR5和CXCR4），其使用贝叶斯分类器导致细胞CD4中的艾滋病（HIV-1）
10. Elucidating the Functions and Signaling Mechanisms of the Chemokine CXCL12 and Its Receptors CXCR4 and CXCR7 in Cancer. [D] . O'Hayre, Morgan L. 2011

机译：阐明趋化因子CXCL12及其受体CXCR4和CXCR7在癌症中的功能和信号传导机制。
11. Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3 [O] . Philip M. Murphy, Lauren Heusinkveld -1

机译：CXCL12及其受体CXCR4和ACKR3的多系统多任务处理
12. Differential activity and selectivity of N‐terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors [O] . Agnieszka Jaracz‐Ros, Guillaume Bernadat, Pasquale Cutolo, 2020

机译：N-末端改性CXCL12趋化因子在CXCR4和ACKR3受体中的差异活性和选择性
13. CXCL14 Blockade of CXCL12/CXCR4 Signaling in Prostate Cancer Bone Metastasis. [R] . Clines, G. A. 2017

机译：CXCL14阻断前列腺癌骨转移中CXCL12 / CXCR4信号转导。

Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3

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